Prenatal diagnosis of nonrhizomelic chondrodysplasiapunctata (Conradi-HÜnermann syndrome)
dc.contributor.author | Pryde, Peter G. | en_US |
dc.contributor.author | Bawle, Erawati V. | en_US |
dc.contributor.author | Brandt, Francisco | en_US |
dc.contributor.author | Romero, Roberto | en_US |
dc.contributor.author | Treadwell, Marjorie C. | en_US |
dc.contributor.author | Evans, Mark I. | en_US |
dc.date.accessioned | 2006-04-28T16:48:44Z | |
dc.date.available | 2006-04-28T16:48:44Z | |
dc.date.issued | 1993-09-01 | en_US |
dc.identifier.citation | Pryde, Peter G.; Bawle, Erawati; Brandt, Francisco; Romero, Roberto; Treadwell, Marjorie C.; Evans, Mark I. (1993)."Prenatal diagnosis of nonrhizomelic chondrodysplasiapunctata (Conradi-HÜnermann syndrome)." American Journal of Medical Genetics 47(3): 426-431. <http://hdl.handle.net/2027.42/38259> | en_US |
dc.identifier.issn | 0148-7299 | en_US |
dc.identifier.issn | 1096-8628 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38259 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8135294&dopt=citation | en_US |
dc.description.abstract | Chondrodysplasia punctata has been classified into two major types including the rare autosomal recessive “rhizomelic type” and a more common but genetically heterogenous nonrhizomelic type (referrred to by some authors as “Sonradi-HÜnermann (CH) type”). The former is typically lethal, manifesting serious anomalies, and allowing several instances of confident prenatal diagnosis. The latter being milder has more subtle anomalies and prenatal diagnosis has been uncommonly reported (confined to cases diagnosed incidentally by flat-plate X-ray examination of the mother in late third trimester, and a case found by directed ultrasound performed in a mandelian affected mother). Cases included (1) a young primigravida thought to be affected with Conradi-HÜnermann syndrome presented at 16 weeks gestation for prenatal diagnosis and counseling. Ultrasound examination of the fetus detected assymetric limb shortness allowing the presumptive diagnosis of an affected fetus which was confirmed after delivery near term. (2) A normal 38-year-old multipara with unremarkable family history underwent routine fetal ultrasound evaluation at 18 weeks gestation. Disorganization of the spine, premature echogenicity of femorl epipheses, and frontal bossing with depressed nasal bridge were described. Neonatal examination confirmed suspicion of CH. Case 1 demonstrates the importance of solid clinical diagnosis in Mendelian malformation-affected parents for directing prenatal diagnostic efforts. Case 2 represents the first index case of CH diagnosed antenatally by ultrasound. Diagnostic clues which must be considered in establishing these diagnoses are discussed, as are some of the difficulties and limitations in antenatal counseling such cases. © 1993 Wiley-Liss, Inc. | en_US |
dc.format.extent | 671565 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Prenatal diagnosis of nonrhizomelic chondrodysplasiapunctata (Conradi-HÜnermann syndrome) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Divisions of Reproductive Genetics, Childrens Hospital of Michigan/Wayne State University, Detroit, Michiga ; Division of Reproductive Genetics, Department of Obstetrics/Gynecology, Hutzel Hospital/Wayne State University. 4707 St Antoine Boulevard, Detroit, Michigan 48201 | en_US |
dc.contributor.affiliationother | Department of Obstetrics and Gynecology, Hutzel Hospital/Wayne State University, and Pediatric Metabolic and Genetic Diseases, Childrens Hospital of Michigan/Wayne State University, Detroit, Michiga | en_US |
dc.contributor.affiliationother | Maternal Fetal Medicine, Childrens Hospital of Michigan/Wayne State University, Detroit, Michiga | en_US |
dc.contributor.affiliationother | Maternal Fetal Medicine, Childrens Hospital of Michigan/Wayne State University, Detroit, Michiga | en_US |
dc.contributor.affiliationother | Maternal Fetal Medicine, Childrens Hospital of Michigan/Wayne State University, Detroit, Michiga | en_US |
dc.contributor.affiliationother | Divisions of Reproductive Genetics, Childrens Hospital of Michigan/Wayne State University, Detroit, Michiga | en_US |
dc.identifier.pmid | 8135294 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38259/1/1320470327_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/ajmg.1320470327 | en_US |
dc.identifier.source | American Journal of Medical Genetics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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