Extraction of aminoglycoside antibiotics with reverse micelles
dc.contributor.author | Hu, Ziyi | en_US |
dc.contributor.author | Gulari, Erdogan | en_US |
dc.date.accessioned | 2006-04-28T16:50:47Z | |
dc.date.available | 2006-04-28T16:50:47Z | |
dc.date.issued | 1996-01 | en_US |
dc.identifier.citation | Hu, Ziyi; Gulari, Erdogan (1996)."Extraction of aminoglycoside antibiotics with reverse micelles." Journal of Chemical Technology AND Biotechnology 65(1): 45-48. <http://hdl.handle.net/2027.42/38295> | en_US |
dc.identifier.issn | 0268-2575 | en_US |
dc.identifier.issn | 1097-4660 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38295 | |
dc.description.abstract | The reverse micelle system of sodium di-2-ethylhexyl phosphate was used to extract aminoglycoside antibiotics, neomycin and gentamicin. The aminoglycosides can be efficiently extracted into a reverse micelle solution, and the antibiotics extracted into the micelle phase can readily be recovered back to a divalent cation aqueous solution, such as Ca 2+ . The transfer efficiency, % E , is heavily dependent on pH and salt concentration in the aqueous feed solution. % E decreases drastically with pH in the pH range 8·5–11, and declines with increasing (NH 4 ) 2 SO 4 concentration. A simple transfer mechanism was proposed which suggests that the antibiotic molecules were extracted into the inner water cores of reverse micelles through attractive electrostatic interaction during forward transfer. In backward transfer, the antibiotics loaded in the micelle phase are released back to an aqueous phase through breaking up of the reverse micelles by using divalent cation solutions. The model is supported by the results of dynamic light scattering and infra-red spectroscopy study. | en_US |
dc.format.extent | 342201 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Biochemistry and Biotechnology | en_US |
dc.title | Extraction of aminoglycoside antibiotics with reverse micelles | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, Michigan, USA ; Department of Chemical Engineering, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38295/1/390_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1097-4660(199601)65:1<45::AID-JCTB390>3.0.CO;2-9 | en_US |
dc.identifier.source | Journal of Chemical Technology AND Biotechnology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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