Treatment of Wilson's disease with zinc. I. Oral zinc therapy regimens
dc.contributor.author | Hill, Gretchen M. | en_US |
dc.contributor.author | Brewer, George J. | en_US |
dc.contributor.author | Prasad, Ananda S. | en_US |
dc.contributor.author | Hydrick, Connie R. | en_US |
dc.contributor.author | Hartmann, Deborah E. | en_US |
dc.date.accessioned | 2006-04-28T16:52:57Z | |
dc.date.available | 2006-04-28T16:52:57Z | |
dc.date.issued | 1987-05 | en_US |
dc.identifier.citation | Hill, Gretchen M.; Brewer, George J.; Prasad, Ananda S.; Hydrick, Connie R.; Hartmann, Deborah E. (1987)."Treatment of Wilson's disease with zinc. I. Oral zinc therapy regimens." Hepatology 7(3): 522-528. <http://hdl.handle.net/2027.42/38334> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38334 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3570163&dopt=citation | en_US |
dc.description.abstract | The standard therapy for preventing copper accumulation in Wilson's disease, D-penicillamine, has been a life-saving drug, but it has many side effects and some patients are completely intolerant. We have been using oral zinc as another approach to the therapy for Wilson's disease, with copper balance studies as the key initial assessment of the adequacy of a given dose or regimen of zinc therapy. We earlier reported that an intensive regimen of zinc (zinc taken every 4 hr) was effective in controlling copper balance. We have now shown with balance studies that a simplified zinc therapy regimen of 50 mg zinc taken 3 times per day is effective in controlling copper balance. Preliminary work presented here with other simplified regimens also indicate their effectiveness. These studies increase the data base, in terms of copper balance, for zinc therapy of Wilson's disease, and expand the dose range and regimens of zinc which have been shown to control copper balance. | en_US |
dc.format.extent | 718846 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | W.B. Saunders | en_US |
dc.publisher | Wiley Periodiocals, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Treatment of Wilson's disease with zinc. I. Oral zinc therapy regimens | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine and the Clinical Research Center, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Internal Medicine, Wayne State University and Wayne State University School of Medicine, Detroit, Michigan 48201 ; Veterans Administration Hospital, Allen Park, Michigan 48101 ; University of Missouri-Columbia, College of Home Economics, Department of Human Nutrition Foods and Foods Systems Management, Columbia, Missouri 65211 | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine and the Clinical Research Center, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Internal Medicine, Wayne State University and Wayne State University School of Medicine, Detroit, Michigan 48201 ; Veterans Administration Hospital, Allen Park, Michigan 48101 ; University of Missouri-Columbia, College of Home Economics, Department of Human Nutrition Foods and Foods Systems Management, Columbia, Missouri 65211 ; Professor of Human Genetics and Internal Medicine, University of Michigan Medical School, Department of Human Genetics, 4708 Med Sci II, Box 0618. Ann Arbor, Michigan 48109–0618 | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine and the Clinical Research Center, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Internal Medicine, Wayne State University and Wayne State University School of Medicine, Detroit, Michigan 48201 ; Veterans Administration Hospital, Allen Park, Michigan 48101 ; University of Missouri-Columbia, College of Home Economics, Department of Human Nutrition Foods and Foods Systems Management, Columbia, Missouri 65211 | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine and the Clinical Research Center, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Internal Medicine, Wayne State University and Wayne State University School of Medicine, Detroit, Michigan 48201 ; Veterans Administration Hospital, Allen Park, Michigan 48101 ; University of Missouri-Columbia, College of Home Economics, Department of Human Nutrition Foods and Foods Systems Management, Columbia, Missouri 65211 | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Internal Medicine and the Clinical Research Center, University of Michigan, Ann Arbor, Michigan 48109 ; Department of Internal Medicine, Wayne State University and Wayne State University School of Medicine, Detroit, Michigan 48201 ; Veterans Administration Hospital, Allen Park, Michigan 48101 ; University of Missouri-Columbia, College of Home Economics, Department of Human Nutrition Foods and Foods Systems Management, Columbia, Missouri 65211 | en_US |
dc.identifier.pmid | 3570163 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38334/1/1840070318_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.1840070318 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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