Lichen planus and the liver
dc.contributor.author | Gumucio, Jorge J. | en_US |
dc.contributor.author | Powell, Frank C. | en_US |
dc.contributor.author | Rogers, Roy S. | en_US |
dc.contributor.author | Dickson, E. Rolland | en_US |
dc.date.accessioned | 2006-04-28T16:53:54Z | |
dc.date.available | 2006-04-28T16:53:54Z | |
dc.date.issued | 1991-03 | en_US |
dc.identifier.citation | Gumucio, Jorge J.; Powell, Frank C.; Rogers, Roy S.; Dickson, E. Rolland (1991)."Lichen planus and the liver." Hepatology 13(3): 609-611. <http://hdl.handle.net/2027.42/38352> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38352 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1999330&dopt=citation | en_US |
dc.description.abstract | Objective – To assess the association of lichen planus with liver complaints and with known etiological factors of liver diseases. Design – A multicentre case-control study. Interviews were conducted by trained medical investigators on the basis of a structured questionnaire. At the interview patients and controls were asked for consent to blood samples being taken to determine transaminase activities and the presence of hepatitis B virus surface antigen. Setting – Outpatient departments of 27 Italian general and teaching hospitals that were collaborating in the Gruppo Italiano Studi Epidemiologici in Dermatologia (GISED). Subjects – Incident cases and controls were eligible. A total of 577 patients with lichen planus and 1031 controls with dermatological diseases other than lichen planus were interviewed. Less than 1% of the people contacted refused to participate. Patients and controls were matched for sex and age in 5 year intervals. Results – The risk of lichen planus was higher in patients with a history of liver diseases requiring hospital admission or specialist consultation (relative risk = 1.6; 95% confidence interval = 1.2 to 2.2), those who had had liver biopsy (5.5; 1.9 to 15.6) and those with a history of viral hepatitis (1.9; 1.1 to 3.1). High activities of liver enzymes and positive results of tests for hepatitis B virus surface antigen were also associated with lichen planus. The association with alcohol consumption was not clearly confirmed by a dose-risk relationship. Conclusion – This study adds quantitative epidemiological evidence to the clinical observation that liver disease is a risk factor for lichen planus although not a specific marker of it. | en_US |
dc.format.extent | 418757 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | W.B. Saunders | en_US |
dc.publisher | Wiley Periodiocals, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Lichen planus and the liver | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Gastroenterology, Room 111D, VA Medical Center/University of Michigan, Ann Arbor, Michigan 48105 | en_US |
dc.contributor.affiliationother | Regional Center of Dermatology, Mater Hospital, Dublin, Ireland | en_US |
dc.contributor.affiliationother | Department of Dermatology, Mayo Clinic, Rochester, Minnesota 55905 | en_US |
dc.contributor.affiliationother | Division of Gastroenterology, Mayo Clinic, Rochester, Minnesota 55905 | en_US |
dc.identifier.pmid | 1999330 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38352/1/1840130336_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.1840130336 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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