Lectin reactivities as intermediate biomarkers in premalignant colorectal epithelium
dc.contributor.author | Boland, C. Richard | en_US |
dc.contributor.author | Martin, Maria A. | en_US |
dc.contributor.author | Goldstein, Irwin J. | en_US |
dc.date.accessioned | 2006-04-28T16:58:52Z | |
dc.date.available | 2006-04-28T16:58:52Z | |
dc.date.issued | 1992 | en_US |
dc.identifier.citation | Boland, C. Richard; Martin, Maria A.; Goldstein, Irwin J. (1992)."Lectin reactivities as intermediate biomarkers in premalignant colorectal epithelium." Journal of Cellular Biochemistry 50(S16G): 103-109. <http://hdl.handle.net/2027.42/38451> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38451 | |
dc.description.abstract | Normal colonic epithelial cells undergo maturation as they traverse the crypt to the lumenal surface. The binding of lectins to goblet cell mucins and other glycoconjugates changes as the cells migrate and differentiate. Additional stepwise modifications in glycoconjugate expression occur in premalignant and malignant neoplasms that may be detected by lectin binding studies. The lectins Dolichos biflorus agglutinin (DBA) and soybean agglutinin (SBA) have been developed as markers of differentiation in normal-appearing colonic epithelium. Using a quantitative biometric system to score tissues, reduced levels of lectin binding have been found in rectal tissue from patiensts with familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer. The lectin Amaranthus caudatus agglutinin (ACA) binds to a cytoplasmic glycoconjugate expressed at the base of the colonic crypt and serves as a possible proliferation marker in the distal, but not proximal, colon. ACA binding increases in tandem with increased levels of proliferation (using Brdu incorporation ) in neoplastic tissues. Binding by the peanut lectin (PNA) occurs late in the adenoma-to-carcinoma sequence - in larger adenomas and in cancers - and serves as a marker of advancing neoplasia. Lectins identity the stepwise changes that occur during normal diferentation, proliferation and in advancing neoplasia. By selecting the appropriate probe, biomarkers may be developed for early, intermediate, and late events in colorectal cancer. | en_US |
dc.format.extent | 551210 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Lectin reactivities as intermediate biomarkers in premalignant colorectal epithelium | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Biological Chemistry, University of Michigan School of Medicine and Veterans Affairs Medical Center, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Biological Chemistry, University of Michigan School of Medicine and Veterans Affairs Medical Center, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | Departments of Internal Medicine and Biological Chemistry, University of Michigan School of Medicine and Veterans Affairs Medical Center, Ann Arbor, Michigan 48109 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38451/1/240501119_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jcb.240501119 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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