Blood group antigens and integrins as biomarkers in head and neck cancer: Is aberrant tyrosine phosphorylation the cause of altered Α6Β4 integrin expression?
dc.contributor.author | Carey, Thomas E. | en_US |
dc.contributor.author | Nair, Thankam S. | en_US |
dc.contributor.author | Chern, Catherine | en_US |
dc.contributor.author | Liebert, Monica | en_US |
dc.contributor.author | Grossman, H. Barton | en_US |
dc.contributor.author | Wolf, Gregory T. | en_US |
dc.contributor.author | Van Waes, Carter | en_US |
dc.date.accessioned | 2006-04-28T16:59:01Z | |
dc.date.available | 2006-04-28T16:59:01Z | |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Carey, Thomas E.; Nair, Thankam S.; Chern, Catherine; Liebert, Monica; Grossman, H. Barton; Wolf, Gregory T.; Van Waes, Carter (1993)."Blood group antigens and integrins as biomarkers in head and neck cancer: Is aberrant tyrosine phosphorylation the cause of altered Α6Β4 integrin expression?." Journal of Cellular Biochemistry 53(S17F): 223-232. <http://hdl.handle.net/2027.42/38454> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38454 | |
dc.description.abstract | Head and neck cancer is a capricious disease that varies greatly in its clinical behavior. The development of biomarkers that can distinguish between biologically aggressive and indolent tumors has been a long term goal of our laboratories. Predictive markers applicable to biopsy specimens should facilitate clinical management through early identification of patients at greatest risk for early relapse or metastatic spread. Two prominent cell surface markers that we identified by raising monoclonal antibodies to squamous cell carcinomas are blood group antigens and the A9 antigen/Α6Β4 integrin. Both of these markers are abnormally displayed in squamous cancers of the head and neck and serve as indicators of early relapse. Loss of blood group antigen expression is a stronger single indicator than is overexpression of the Α6Β4 integrin. However, use of both markers together is a stronger predictive indicator than is either alone. We know little about the function of the blood group antigens in squamous cells except that the mature antigens are associated with differentiation. Similarly, the function of the Α6Β4 integrin is also not fully understood. Integrin Α6Β4 is thought to serve as an extracellular matrix receptor, but its ligand has not been confirmed. In resting epithelium, the Α6Β4 integrin is polarized to the basal aspect of the basal cell as a component of the hemidesmosome, the anchoring structures of the epithelia. This basal polarization is lost in migrating normal squamous cells and squamous carcinomas. Tyrosine phosphorylation of the Β4 subunit is absent or greatly reduced in malignant cells and this may be a critical signal for subcellular localization of Α6Β4 and cell anchoring. On the basis of our current experimental results, we postulate that tyrosine phosphorylation of the Β4 subunit is a reversible signal that regulates cell migration in normal and malignant cells, and may therefore be an important initial event in the metastatic cascade. | en_US |
dc.format.extent | 902355 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Blood group antigens and integrins as biomarkers in head and neck cancer: Is aberrant tyrosine phosphorylation the cause of altered Α6Β4 integrin expression? | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Laboratory of Cancer Biology, Department of Otolaryngology/Head and Neck Surgery, University of Michigan Cancer Center, Ann Arbor MI 48109-0506 ; Laboratory of Head and Neck Cancer Biology, 6020 KHRI, The University of Michigan, 1301 East Ann Street, Ann Arbor, MI 48109-0506 | en_US |
dc.contributor.affiliationum | Laboratory of Cancer Biology, Department of Otolaryngology/Head and Neck Surgery, University of Michigan Cancer Center, Ann Arbor MI 48109-0506 | en_US |
dc.contributor.affiliationum | Laboratory of Cancer Biology, Department of Otolaryngology/Head and Neck Surgery, University of Michigan Cancer Center, Ann Arbor MI 48109-0506 | en_US |
dc.contributor.affiliationum | Urologic Oncology Laboratory (HBG, ML), Department of Surgery, University of Michigan Cancer Center, Ann Arbor MI 48109-0506 | en_US |
dc.contributor.affiliationum | Urologic Oncology Laboratory (HBG, ML), Department of Surgery, University of Michigan Cancer Center, Ann Arbor MI 48109-0506 | en_US |
dc.contributor.affiliationum | Laboratory of Cancer Biology, Department of Otolaryngology/Head and Neck Surgery, University of Michigan Cancer Center, Ann Arbor MI 48109-0506 | en_US |
dc.contributor.affiliationum | Laboratory of Cancer Biology, Department of Otolaryngology/Head and Neck Surgery, University of Michigan Cancer Center, Ann Arbor MI 48109-0506 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38454/1/240531033_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jcb.240531033 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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