Surrogate endpoint biomarkers for cervical cancer chemoprevention trials
dc.contributor.author | Ruffin, Mack T. | en_US |
dc.contributor.author | Ogaily, Mohammed S. | en_US |
dc.contributor.author | Johnston, Carolyn M. | en_US |
dc.contributor.author | Gregoire, Lucie | en_US |
dc.contributor.author | Lancaster, Wayne D. | en_US |
dc.contributor.author | Brenner, Dean E. | en_US |
dc.date.accessioned | 2006-04-28T16:59:16Z | |
dc.date.available | 2006-04-28T16:59:16Z | |
dc.date.issued | 1995 | en_US |
dc.identifier.citation | Ruffin, Mack T.; Ogaily, Mohammed S.; Johnston, Carolyn M.; Gregoire, Lucie; Lancaster, Wayne D.; Brenner, Dean E. (1995)."Surrogate endpoint biomarkers for cervical cancer chemoprevention trials." Journal of Cellular Biochemistry 59(S23): 113-124. <http://hdl.handle.net/2027.42/38459> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38459 | |
dc.description.abstract | Cervical intraepithelia neoplasia (CIN) represents a spectrum of epithelial changes that provide an excellent model for developing chemopreventive interventions for cervical cancer. Possible drug effect surrogate endpoint biomarkers are dependent on the agent under investigation. Published and preliminary clinical reports suggest retinoids and carotenoids are effective chemopreventive agents for CIN. Determination of plasma and tissue pharmacology of these agents and their metabolites could serve as drug effect intermediate endpoints. In addition, retinoic acid receptors could serve as both drug and biological effect intermediate endpoints. Possible biological effect surrogate endpoint biomarkers include cytomorphological parameters, proliferation markers, genomic markers, regulatory markers, and differentiation. Given the demonstrated causality of human papillomavirus (HPV) for cervical cancer, establishing the relationship to HPV will be an essential component of any biological intermediate endpoint biomarker. The pathologic effect surrogate endpoint biomarker for cervical cancer is CIN, used clinically for years. The desired effect for chemopreventive trials is complete regression or prevention of progression. In planning chemopreventive trials, investigators need to consider spontaneous regression rates, the subjective nature of detecting CIN, and the impact of biopsy on regression. If intermediate endpoint biomarkers that met the above criteria were available for cervical cancer, then new chemopreventive agents could be rapidly explored. The efficacy of these new agents could be determined with a moderate number of subjects exposed to minimal risk over an acceptable amount of time. The impacts on health care for women would be significant. | en_US |
dc.format.extent | 1182993 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Surrogate endpoint biomarkers for cervical cancer chemoprevention trials | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Family Practice, University of Michigan Medical Center, Ann Arbor, MI 48109–0708 | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Division of Hematology and Oncology, Simpson Memorial Institute, Ann Arbon, MI 48109–0724 | en_US |
dc.contributor.affiliationother | Department of Obsterics and Gynecology, Division of Gynecologic Oncology, Ann Arbor, MI 48109–0718 | en_US |
dc.contributor.affiliationother | Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI 48201 | en_US |
dc.contributor.affiliationother | Department of Obstetrics and Gynecology, Center for Molecular Medicine and Genetics, Detroit, MI 48201 | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Division of Hematology and Oncology, Simpson Memorial Institute, Ann Arbor, MI 48109–0724 ; Department of Internal Medicine, Division of Hematology and Oncology, Simpson Memorial Institute, 102 Observatory Street, Ann Arbor, MI 48109-0724 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38459/1/240590915_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jcb.240590915 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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