Effect of organ site on nuclear matrix protein composition
dc.contributor.author | Replogle-Schwab, Tracy S. | en_US |
dc.contributor.author | Getzenberg, Robert H. | en_US |
dc.contributor.author | Donat, Terry L. | en_US |
dc.contributor.author | Pienta, Kenneth J. | en_US |
dc.date.accessioned | 2006-04-28T16:59:25Z | |
dc.date.available | 2006-04-28T16:59:25Z | |
dc.date.issued | 1996-07 | en_US |
dc.identifier.citation | Replogle-Schwab, Tracy S.; Getzenberg, Robert H.; Donat, Terry L.; Pienta, Kenneth J. (1996)."Effect of organ site on nuclear matrix protein composition." Journal of Cellular Biochemistry 62(1): 132-141. <http://hdl.handle.net/2027.42/38462> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38462 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8836882&dopt=citation | en_US |
dc.description.abstract | The nuclear matrix has been linked to several important cellular functions within cells, such as DNA organization and replication, as well as regulation of gene expression. It has been reported that the nuclear matrix protein composition is altered in cells grown on different extracellular matrices in vitro. This study examined the nuclear matrix protein composition of tumors produced by MAT-LyLu (MLL) rat prostate tumor cells implanted at different organ sites within the rat. When high resolution two-dimensional gels were utilized to compare nuclear matrix protein composition to the prostate orthotopic tumor, it was found that there were distinct protein differences depending upon where the tumor grew. In particular, there were 14 proteins found in the lung, six proteins found in intramuscular, 17 proteins is the heart, and five proteins in the tail vein tumor tissue that were not present in the prostate orthotopic tumor tissue. Therefore, this study adds evidence to support that the nuclear matrix composition of a cell is dependent, at least in part, by the extracellular matrix and/or different cellular environments and may have a role in site-specific differences in tumor properties. © 1996 Wiley-Liss, Inc. | en_US |
dc.format.extent | 817095 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Effect of organ site on nuclear matrix protein composition | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The University of Michigan Comprehensive Cancer Center and Division of Hematology/Oncology, Department of Internal Medicine, Ann Arbor, Michigan, 48109-0680 | en_US |
dc.contributor.affiliationum | The University of Michigan Comprehensive Cancer Center and Division of Hematology/Oncology, Department of Internal Medicine, Ann Arbor, Michigan, 48109-0680 ; The University of Michigan Comprehensive Cancer Center and Division of Hematology/Oncology, Department of Internal Medicine, 5510 MSRB I, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0680 | en_US |
dc.contributor.affiliationother | University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213-2582 | en_US |
dc.contributor.affiliationother | Wayne State University School of Medicine, Department of Otolaryngology/HNS, Detroit, Michigan 48201 | en_US |
dc.identifier.pmid | 8836882 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38462/1/14_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/(SICI)1097-4644(199607)62:1<132::AID-JCB14>3.0.CO;2-P | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.