Detection of liver fibrosis with magnetic cross-relaxation
dc.contributor.author | Aisen, Alex M. | en_US |
dc.contributor.author | Doi, Kei | en_US |
dc.contributor.author | Swanson, Scott D. | en_US |
dc.date.accessioned | 2006-04-28T17:00:47Z | |
dc.date.available | 2006-04-28T17:00:47Z | |
dc.date.issued | 1994-05 | en_US |
dc.identifier.citation | Aisen, Alex M.; Doi, Kei; Swanson, Scott D. (1994)."Detection of liver fibrosis with magnetic cross-relaxation." Magnetic Resonance in Medicine 31(5): 551-556. <http://hdl.handle.net/2027.42/38490> | en_US |
dc.identifier.issn | 0740-3194 | en_US |
dc.identifier.issn | 1522-2594 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38490 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8015410&dopt=citation | en_US |
dc.description.abstract | The utility of MRI using magnetization transfer (MT) enhanced pulse sequences to diagnose hepatic cirrhosis in a rat model was investigated. Hepatic T 1 was measured with and without MT off-resonance RF pulses in 17 treated and six control rats. The livers were evaluated histologically, and the hydroxyproline content quantitatively measured. We did not find a statistically significant linear correlation between the MR relaxation times and the degree of tissue injury. However, the MR measurements performed with MT were superior to those without differentiating the treated and control groups. Specifically, the T 1 times were 695 ±76 ms for the treated group, versus 748 ± 61 ms in the controls; P = 0.095. The T 1sat times were also lower in the treated group, with statistical significance: 367 ± 51 ms versus 421 ± 38 ms, P = 0.016. Finally, the change in the relaxation rates (the inverse of the relaxation times) with and without saturation were 1.31 ± 0.22 s −1 (treated group) versus 1.05 ± 0.12 s −1 (controls), which differed significantly, P = 0.001. | en_US |
dc.format.extent | 730969 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Imaging | en_US |
dc.title | Detection of liver fibrosis with magnetic cross-relaxation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Radiology, The University of Michigan, Ann Arbor, Michigan ; Department of Radiology, University of Michigan Hospitals, R3301 Kresge 111/Box 0553, Ann Arbor, MI 48109-0553 | en_US |
dc.identifier.pmid | 8015410 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38490/1/1910310513_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/mrm.1910310513 | en_US |
dc.identifier.source | Magnetic Resonance in Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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