Detection of genome similarity as an exploratory tool for mapping complex traits
dc.contributor.author | Guo, Sun-Wei | en_US |
dc.date.accessioned | 2006-04-28T17:01:37Z | |
dc.date.available | 2006-04-28T17:01:37Z | |
dc.date.issued | 1995 | en_US |
dc.identifier.citation | Guo, Sun-Wei (1995)."Detection of genome similarity as an exploratory tool for mapping complex traits." Genetic Epidemiology 12(6): 877-882. <http://hdl.handle.net/2027.42/38507> | en_US |
dc.identifier.issn | 0741-0395 | en_US |
dc.identifier.issn | 1098-2272 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38507 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8788025&dopt=citation | en_US |
dc.description.abstract | For one- and two-trait-locus models, we show that the lod score based on affected relative pairs or trios is a monotonically increasing function of the genome similarity measured by the proportion of alleles shared identical by descent (IBD) conditional on observed marker data. These results can be generalized to multitrait-locus models. Thus, we can use conditional probability of genes shared IBD as a tool to reveal chromosomal segments that are likely to harbor the genes underlying the complex traits. © 1995 Wiley-Liss, Inc. | en_US |
dc.format.extent | 311233 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Detection of genome similarity as an exploratory tool for mapping complex traits | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biostatistics, University of Michigan, Ann Arbor, Michigan ; Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109-2029 | en_US |
dc.identifier.pmid | 8788025 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38507/1/1370120658_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/gepi.1370120658 | en_US |
dc.identifier.source | Genetic Epidemiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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