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Computation of multilocus prior probability of autozygosity for complex inbred pedigrees
dc.contributor.authorGuo, Sun-Weien_US
dc.date.accessioned2006-04-28T17:01:43Z
dc.date.available2006-04-28T17:01:43Z
dc.date.issued1997en_US
dc.identifier.citationGuo, Sun-Wei (1997)."Computation of multilocus prior probability of autozygosity for complex inbred pedigrees." Genetic Epidemiology 14(1): 1-15. <http://hdl.handle.net/2027.42/38509>en_US
dc.identifier.issn0741-0395en_US
dc.identifier.issn1098-2272en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/38509
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9055058&dopt=citationen_US
dc.description.abstractHomozygosity mapping is a very powerful method for mapping rare recessive diseases in humans. In many applications, it is often desirable to compute prior (or unconditional) multilocus probability of autozygosity for inbred pedigrees. This paper proposes a simple yet powerful method for computing the prior multilocus autozygosity probability for complex inbred pedigrees. The method has an added feature of providing explicit multilocus autozygosity probability in terms of recombination fractions, if desired. An example is presented to illustrate the method. Genet. Epidemiol. 14:1–15,1997. © 1997 Wiley-Liss, Inc.en_US
dc.format.extent111668 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherGeneticsen_US
dc.titleComputation of multilocus prior probability of autozygosity for complex inbred pedigreesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Biostatistics, University of Michigan, Ann Arbor ; Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029en_US
dc.identifier.pmid9055058en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/38509/1/1_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/(SICI)1098-2272(1997)14:1<1::AID-GEPI1>3.0.CO;2-Cen_US
dc.identifier.sourceGenetic Epidemiologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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