Flow cytometric analysis of cytologic specimens in hematologic disease Presented in part before the International Academy of Pathology, Washington, D.C., February 28-March 3, 1988 (Lab Invest 1988; S8:37A).
dc.contributor.author | Hanson, Curtis A. | en_US |
dc.contributor.author | Schnitzer, Bertram | en_US |
dc.date.accessioned | 2006-04-28T17:02:45Z | |
dc.date.available | 2006-04-28T17:02:45Z | |
dc.date.issued | 1989 | en_US |
dc.identifier.citation | Hanson, Curtis A.; Schnitzer, Bertram (1989)."Flow cytometric analysis of cytologic specimens in hematologic disease Presented in part before the International Academy of Pathology, Washington, D.C., February 28-March 3, 1988 (Lab Invest 1988; S8:37A). ." Journal of Clinical Laboratory Analysis 3(1): 2-7. <http://hdl.handle.net/2027.42/38530> | en_US |
dc.identifier.issn | 0887-8013 | en_US |
dc.identifier.issn | 1098-2825 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38530 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=2715871&dopt=citation | en_US |
dc.description.abstract | Cytologic evaluation of body fluids and fine needle aspirations (FNA) is frequently required in patients with hematologic diseases. In this study we have correlated immunophenotyping and DNA analysis by flow cytometry with cytologic findings and tissue biopsies from 20 patients with body fluid specimens and 5 with FNA. Nineteen of 25 cases, including all FNA cases, had an immunophenotype consistent with malignancy: 12 monoclonal lymphomas, 2 T-cell lymphomas, 2 T-ALL and 3 non-T-ALL. By cytologic examination, 14 of these 19 cases were positive for malignant cells, 2 suspicious and 3 negative; the latter 5 cases, including 2 FNA cases, had small monoclonal B-cell populations detected by flow cytometry. Six cases had a benign immunophenotype; cytologic examination was benign in 4 of these and suspicious for lymphoma in 2. Our results show the feasibility of using flow cytometry to evaluate body fluids or FNA and demonstrate that small malignant populations that may be missed by routine cytology can be detected by flow cytometry. | en_US |
dc.format.extent | 528472 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | Flow cytometric analysis of cytologic specimens in hematologic disease Presented in part before the International Academy of Pathology, Washington, D.C., February 28-March 3, 1988 (Lab Invest 1988; S8:37A). | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pathology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Pathology, University of Michigan Medical School, MS242 Medical Science I, Ann Arbor, MI 48109-00602 | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 2715871 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38530/1/1860030103_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jcla.1860030103 | en_US |
dc.identifier.source | Journal of Clinical Laboratory Analysis | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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