Enantioselective detoxication of optical isomers of glycidyl ethers
dc.contributor.author | Chen, Ruth R. | en_US |
dc.contributor.author | Nguyen, Phuong | en_US |
dc.contributor.author | You, Zhengqing | en_US |
dc.contributor.author | Sinsheimer, Joseph E. | en_US |
dc.date.accessioned | 2006-04-28T17:02:51Z | |
dc.date.available | 2006-04-28T17:02:51Z | |
dc.date.issued | 1993 | en_US |
dc.identifier.citation | Chen, Ruth; Nguyen, Phuong; You, Zhengqing; Sinsheimer, Joseph E. (1993)."Enantioselective detoxication of optical isomers of glycidyl ethers." Chirality 5(7): 501-504. <http://hdl.handle.net/2027.42/38532> | en_US |
dc.identifier.issn | 0899-0042 | en_US |
dc.identifier.issn | 1520-636X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38532 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8240926&dopt=citation | en_US |
dc.description.abstract | The detoxication of the enantiomers of glycidyl 4-nitrophenyl ether (GNPE), (−)-(R)- and (+)-(S)-GNPE, and glycidyl 1-naphthyl ether (GNE), (−)-(R)- and (+)-(S)-GNE, by rat liver glutathione transferase and epoxide hydrolase was studied. Enantioselectivity was observed with both enzymes favoring the (R)-isomers as determined by the formation of conjugate, diol, and remaining substrate measured by HPLC. Enantiomers of GNE were detoxified by cytosolic epoxide hydrolase but those of GNPE were not. Substantial nonenzymatically formed conjugates of enantiomers of GNPE were detected showing (S)-GNPE the more reactive of the pair. © 1993 Wiley-Liss, Inc. | en_US |
dc.format.extent | 414118 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Alan R. Liss, Inc. | en_US |
dc.publisher | Wiley Periodiocals, Inc. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Organic Chemistry | en_US |
dc.title | Enantioselective detoxication of optical isomers of glycidyl ethers | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, Ann Arbor, Michigan ; College of Pharmacy, University of Michigan, Ann Arbor, MI 48109–1065 | en_US |
dc.identifier.pmid | 8240926 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38532/1/530050705_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/chir.530050705 | en_US |
dc.identifier.source | Chirality | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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