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Developmental, genetic, and environmental components of lung volumes at high altitude

dc.contributor.authorFrisancho, A. Robertoen_US
dc.contributor.authorFrisancho, Hedy G.en_US
dc.contributor.authorAlbalak, Rachelen_US
dc.contributor.authorVillain, Mercedesen_US
dc.contributor.authorVargas, Enriqueen_US
dc.contributor.authorSoria, Rudyen_US
dc.date.accessioned2006-04-28T17:04:31Z
dc.date.available2006-04-28T17:04:31Z
dc.date.issued1997en_US
dc.identifier.citationFrisancho, A. Roberto; Frisancho, Hedy G.; Albalak, Rachel; Villain, Mercedes; Vargas, Enrique; Soria, Rudy (1997)."Developmental, genetic, and environmental components of lung volumes at high altitude." American Journal of Human Biology 9(2): 191-203. <http://hdl.handle.net/2027.42/38564>en_US
dc.identifier.issn1042-0533en_US
dc.identifier.issn1520-6300en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/38564
dc.description.abstractVital capacity and residual lung volume (in terms of 1/min or ml/m 2 of body surface area) of 357 subjects (205 males, 152 females) was evaluated in La Paz, Bolivia, situated at 3,750 m. The sample included: (1) 37 high altitude rural natives (all male), (2) 125 high altitude urban natives (69 male, 58 female), (3) 85 Bolivians of foreign ancestry acclimatized to high altitude since birth (40 male, 45 female), (4) 63 Bolivians of foreign ancestry acclimatized to high altitude during growth (30 male, 33 female), and (5) 47 non-Bolivians of either European or North American ancestry acclimatized to high altitude during adulthood (24 male, 23 female). Results indicate that (1) all samples studied, irrespective of origin or acclimatization status, have larger lung volumes than those predicted from sea level norms; (2) the high altitude rural natives have significantly greater lung volumes (vital capacity and residual lung volume) than the high altitude urban natives and all the non-native high altitude samples; (3) males acclimatized to high altitude since birth or during growth attain similar lung volumes as high altitude urban natives and higher residual lung volumes than subjects acclimatized to high altitude during adulthood but lower than the high altitude rural natives; (4) females acclimatized to high altitude since birth or during growth attain similar lung volumes as subjects acclimatized to high altitude during adulthood; (5) age at arrival to high altitude is inversely related to residual lung volume but not vital capacity; (6) among subjects acclimatized to high altitude during growth, approximately 20–25% of the variability in residual lung volume can be explained by developmental factors; (7) among high altitude rural and urban natives, it appears that approximately 20–25% of the variability in residual lung volume at high altitude can be explained by genetic traits associated with skin reflectance and genetic traits shared by siblings; and (8) vital capacity, but not the residual lung volume, is inversely related to occupational activity level. Together these data suggest that the attainment of vital capacity at high altitude is influenced more by environmental factors, such as occupational activity level, and body composition than developmental acclimatization. On the other hand, the attainment of an enlarged residual volume is related to both developmental acclimatization and genetic factors. Am. J. Hum. Biol. 9:191–203, 1997. © 1997 Wiley-Liss, Inc.en_US
dc.format.extent262389 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherAnthropologyen_US
dc.titleDevelopmental, genetic, and environmental components of lung volumes at high altitudeen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelMedicine (General)en_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, Michigan 48109 ; Center for Human Growth and Development, 300 N. Ingalls, University of Michigan, Ann Arbor, MI 48109-0406en_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationumUniversity of Michigan, Ann Arbor, Michigan 48109en_US
dc.contributor.affiliationotherInstituto Boliviano de BiologÍa de Altura, La Paz, Boliviaen_US
dc.contributor.affiliationotherInstituto Boliviano de BiologÍa de Altura, La Paz, Boliviaen_US
dc.contributor.affiliationotherInstituto Boliviano de BiologÍa de Altura, La Paz, Boliviaen_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/38564/1/5_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/(SICI)1520-6300(1997)9:2<191::AID-AJHB5>3.0.CO;2-3en_US
dc.identifier.sourceAmerican Journal of Human Biologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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