Preliminary clinical trial of gadodiamide injection: A new nonionic gadolinium contrast agent for MR imaging
dc.contributor.author | Kaplan, George A. | en_US |
dc.contributor.author | Aisen, Alex M. | en_US |
dc.contributor.author | Aravapalli, S. Rao | en_US |
dc.date.accessioned | 2006-04-28T17:04:51Z | |
dc.date.available | 2006-04-28T17:04:51Z | |
dc.date.issued | 1991-01 | en_US |
dc.identifier.citation | Kaplan, Gabriela D.; Aisen, Alex M.; Aravapalli, S. Rao (1991)."Preliminary clinical trial of gadodiamide injection: A new nonionic gadolinium contrast agent for MR imaging." Journal of Magnetic Resonance Imaging 1(1): 57-62. <http://hdl.handle.net/2027.42/38569> | en_US |
dc.identifier.issn | 1053-1807 | en_US |
dc.identifier.issn | 1522-2586 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38569 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1802131&dopt=citation | en_US |
dc.description.abstract | The safety and efficacy of a newly developed intravenous formulation of the nonionic contrast agent gadolinium diethylenetriaminepentaacetic acid- bis (methylamide), formulated as gadodia-mide injection, was investigated. In 30 patients who underwent spin-echo magnetic resonance (MR) imaging before and after contrast agent enhancement, the enhanced images had characteristics judged similar to those of images enhanced by means of available gadolinium compounds. In 15 patients, contrast agent administration was of major diagnostic help, either revealing lesions not apparent without enhancement or providing important lesion characterization. In 12 patients, the lack of abnormal enhancement patterns was important in excluding the presence of disease. In three patients, the contrast agent did not provide information additional to that obtained with the unenhanced T1- and T2-weighted images. No clinically significant changes were observed in vital signs, neurologic status, or laboratory results. The authors conclude that, in this limited series, gadodiamide injection proved to be a safe and useful MR imaging contrast agent for evaluation of the central nervous system and surrounding structures. | en_US |
dc.format.extent | 703768 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Imaging | en_US |
dc.title | Preliminary clinical trial of gadodiamide injection: A new nonionic gadolinium contrast agent for MR imaging | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0030 | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0030 ; Department of Radiology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0030 | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, 1500 E Medical Center Dr, Ann Arbor, MI 48109-0030 | en_US |
dc.identifier.pmid | 1802131 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38569/1/1880010107_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jmri.1880010107 | en_US |
dc.identifier.source | Journal of Magnetic Resonance Imaging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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