MR angiography with an ultrasmall superparamagnetic iron oxide blood pool agent
dc.contributor.author | Anzai, Yoshimi | en_US |
dc.contributor.author | Prince, Martin R. | en_US |
dc.contributor.author | Chenevert, Thomas L. | en_US |
dc.contributor.author | Maki, Jeffrey H. | en_US |
dc.contributor.author | London, Frank Londy Manette | en_US |
dc.contributor.author | McLachlan, Stuart J. | en_US |
dc.date.accessioned | 2006-04-28T17:05:08Z | |
dc.date.available | 2006-04-28T17:05:08Z | |
dc.date.issued | 1997-01 | en_US |
dc.identifier.citation | Anzai, Yoshimi; Prince, Martin R.; Chenevert, Thomas L.; Maki, Jeffrey H.; London, Frank Londy Manette; McLachlan, Stuart J. (1997)."MR angiography with an ultrasmall superparamagnetic iron oxide blood pool agent." Journal of Magnetic Resonance Imaging 7(1): 209-214. <http://hdl.handle.net/2027.42/38575> | en_US |
dc.identifier.issn | 1053-1807 | en_US |
dc.identifier.issn | 1522-2586 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38575 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9039617&dopt=citation | en_US |
dc.description.abstract | The purpose of the study was to investigate the use of a dextran-coated ultrasmall superparamagnetic iron oxide (USPIO) as a blood pool contrast agent for thoracic and abdominal MR angiography. Abdominal and thoracic MR angiography was performed in six healthy volunteers using two-dimensional and three-dimensional spoiled gradient echo (SPGR) sequences before and after intravenous administration of USPIO. Doses ranged from 1.1 to 2.6 mg Fe/kg. Flip angle was varied from 20 to 60°. Subjective image quality, analysis of signal-to-noise ratio (SNR), and blood T1 relaxation times were measured. USPIO significantly lowered the T1 of blood (from 1,210 ms precontrast to 159 ms postcontrast at a dose of 2.6 mg Fe/kg) ( P < .01). Image quality on coronal fast three-dimensional breath-hold SPGR images of the abdomen increased with increasing dose and was maximum at the highest dose, producing an aortic SNR of 9.6 compared to 1.8 precontrast. Axial two-dimensional time-of-flight (TOF) aortic SNR was reduced significantly from 13 on precontrast to 6 on the postcontrast images at the highest dose ( P < .05) due to T2* shortening effects. There was little flip angle dependence on image quality. Due to the T1 shortening effect and long intravascular half-life, USPIO improved visualization of vascular anatomy using three-dimensional fast SPGR imaging. The echo time must be minimized to minimize signal loss from T2* shortening effects. The blood pool distribution of USPIO is useful for equilibriumphase MR angiography. | en_US |
dc.format.extent | 1024 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/octet-stream | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Imaging | en_US |
dc.title | MR angiography with an ultrasmall superparamagnetic iron oxide blood pool agent | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030 ; Department of Radiology, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030 | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030 | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030 | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030 | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0030 | en_US |
dc.contributor.affiliationother | Advanced Magnetics, Inc., Princeton, NJ | en_US |
dc.identifier.pmid | 9039617 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38575/1/sgml.9417 | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/jmri.1880070132 | en_US |
dc.identifier.source | Journal of Magnetic Resonance Imaging | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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