Synthesis and conformation of poly( L -azetidine-2-carboxylic acid- L -proline) and poly([ L -proline] 3 - L -azetidine-2-carboxylic acid)
dc.contributor.author | Tsai, F. -H. | en_US |
dc.contributor.author | Overberger, Charles Gilbert | en_US |
dc.contributor.author | Zand, Robert | en_US |
dc.date.accessioned | 2006-04-28T18:19:12Z | |
dc.date.available | 2006-04-28T18:19:12Z | |
dc.date.issued | 1992-03-30 | en_US |
dc.identifier.citation | Tsai, F. H.; Overberger, C. G.; Zand, R. (1992)."Synthesis and conformation of poly( L -azetidine-2-carboxylic acid- L -proline) and poly([ L -proline] 3 - L -azetidine-2-carboxylic acid)." Journal of Polymer Science Part A: Polymer Chemistry 30(4): 551-559. <http://hdl.handle.net/2027.42/38841> | en_US |
dc.identifier.issn | 0887-624X | en_US |
dc.identifier.issn | 1099-0518 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/38841 | |
dc.description.abstract | The synthesis, characterization, and conformational assessment of po L y( L -Aze- L -Pro) and poly[( L -Pro) 3 - L -Aze] are reported. The polymers were prepared by using the pentachlorophenol active ester as the polymerizable tetrapeptide derivatives. The copolymer, poly( L -Aze- L -Pro), assumes a Form II helix in polar solvents, and is converted into a form I-like helix at a critical solvent composition of ethanol to trifluoroethanol. The CD spectrum of this Form I-like conformation of poly( L -Aze- L -Pro) is similar to that of poly( trans -5-isopropyl- L -proline), indicating that the rigid four-membered ring at the alternating position can lock in the structure by a mechanism similar to that of a bulky substituent at the trans-5-position of proline. The helix conformation of this copolymer was unfolded in a 0.2 M CaCl 2 aqueous solution. In contrast to poly( L -Aze- L -Pro), the copolymer of poly[( L -Pro) 3 - L -Aze] contains both cis and trans peptide bond geometry when dissolved in a 90:10 ETOH-H 2 O mixture. The conversion of the mixed conformation of poly[( L -Pro) 3 - L -Aze)] into a polyproline Form II-like structure occurred in highly polar solvent environments such as water. | en_US |
dc.format.extent | 756984 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | John Wiley & Sons, Inc. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Synthesis and conformation of poly( L -azetidine-2-carboxylic acid- L -proline) and poly([ L -proline] 3 - L -azetidine-2-carboxylic acid) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The Macromolecular Research Center and Department of Chemistry and The Biophysics Research Division and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-2099 | en_US |
dc.contributor.affiliationum | The Macromolecular Research Center and Department of Chemistry and The Biophysics Research Division and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-2099 | en_US |
dc.contributor.affiliationum | The Macromolecular Research Center and Department of Chemistry and The Biophysics Research Division and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109-2099 ; The Macromolecular Research Center, University of Michigan, 2200 Bonisteel Blvd., Ann Arbor, MI 48109-2099 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/38841/1/080300405_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/pola.1992.080300405 | en_US |
dc.identifier.source | Journal of Polymer Science Part A: Polymer Chemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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