Now showing items 1-10 of 2468
Vaccine Induced Protection Against Influenza: Persistence of Serum Antibodies, Vaccine Efficacy as a Function of Time, and Use of Transmission Models to Estimate Vaccine Effectiveness in Household Cohort Studies.
(2016)
Influenza vaccine is currently the best available means of preventing influenza infection, though vaccine effectiveness can vary year to year based on factors such as match between circulating viruses and those included ...
Fear of the Childbirth Experience.
(2015)
For many women having a generalized level of fear and anxiety about the childbirth experience is a normative response. This emotion, for some women, translated into a sense of fear that can become so overwhelming that it ...
Deliberate Practice In Nursing.
(2014)
Purpose: Demands being placed on nursing to maintain competence and strive for expertise attainment are great. Expertise development has been linked to deliberate practice (activities engaged in to improve performance) in ...
Statistical Issues in the Analysis of Correlated Data.
(2015)
We first extend the original classification and regression trees (CART) paradigm (Breiman et al. 1984) to clustered binary outcomes, where individuals within a cluster are correlated. We propose to generate tree models ...
Mapping Microclimate pH in Biodegradable Polymeric Microspheres.
(2013)
The microclimate inside microspheres prepared from biodegradable polymers (e.g., poly(lactic-co-glycolic acid) PLGA) often becomes acidic owing to the accumulation of water-soluble polymer degradation products, which can ...
In Vivo Predictive Dissolution: Analyzing the impact of Bicarbonate Buffer and Hydrodynamics on Dissolution.
(2015)
When a drug is given orally, one of the major factors that impacts safety and efficacy is dissolution rate. Two important in vivo parameters that impact dissolution that are not well accounted for in current dissolution ...
Opioid Regulation of Pair Bonding in the Socially Monogamous Prairie Vole.
(2014)
The socially monogamous prairie vole is an excellent animal model for studies of the neurobiology of selective social attachment. Here, we have demonstrated that monogamous bonds are formed and maintained by a balance ...
New Instrumental Variable Methods for Causal Inference.
(2016)
In observational studies, unmeasured differences between treatment groups often confound the relationship of interest. Instrumental variable (IV) methods can give consistent effect estimates in the presence of this ...
Simultaneous Multislice Functional Magnetic Resonance Imaging.
(2016)
Functional magnetic resonance imaging (fMRI) is a valuable tool for mapping brain activity in many fields. Since functional activity is determined by temporal signal changes, undesired fluctuations from physiological motion ...
Three Studies of Variation in Medical Decision-Making and Care Delivery by Physicians.
(2015)
In this dissertation, I examine the effects of select non-financial factors on the organizational and medical decisions of primary care practice managers, specialist consultants, and Veterans Health Administration (VA) ...