Now showing items 1-7 of 7
Computational Approaches Enabling Disparately Acquired Untargeted LC-MS Metabolomics Data Analysis
(2022)
Metabolomics is the systematic study of small molecule metabolites that are substrates, intermediates, and products of cellular metabolism. Metabolomics assays performed using liquid chromatography- mass spectrometry (LC-MS) ...
Computational Methods for Characterizing Post-translational and Chemical Modifications Found in Open Searches
(2022)
Post-translational modifications (PTMs) govern many processes within cells and understanding their function is critical to both the basic and biomedical sciences. However, identifying modified peptides, particularly ...
Advances in in Vivo Neurochemical Monitoring Using Microdialysis with Liquid Chromatography-Mass Spectrometry
(2020)
Improving our understanding of the central nervous system necessitates developing techniques capable of making neurochemical measurements in the complex extracellular environment of the brain within living animal models. ...
Directed Evolution of Stabilized Peptides with Bacterial Display
(2020)
Interactions between proteins govern cellular and the body’s states, including aberrant interactions found in diseases such as in cancers and infections. Small molecule drugs are not ideal in targeting these interactions ...
High Throughput Experimentation Facilitated Development of Amine-Acid Cross Coupling Reactions
(2023)
High throughput experimentation (HTE) is an important technique which can expedite the hit-to-lead process in drug discovery. The first chapter of this thesis reviews reported applications using HTE in medicinal chemistry ...
Development and Discovery of Novel Inhibitors of Mycobacterium tuberculosis RNA Polymerase for the Treatment of Tuberculosis
(2022)
Tuberculosis (TB) is an infectious pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). It is the leading cause of death from a single bacterial pathogen and second, only to COVID-19, as the deadliest ...
Thermodynamic and Mathematical Relationships for Predicting Cocrystal Stability and Controlling Dissolution - Supersaturation - Precipitation Behavior
(2020)
Although pharmaceutical cocrystals have emerged as a useful strategy for enhancing the solubility, dissolution, and oral bioavailability of poorly water-soluble drugs, their development has thus far been marked by a lack ...