Now showing items 1-10 of 17
Development and characterization of cold-adapted viruses for use as live virus vaccines
(Elsevier, 1985-12)
Representative viruses from twelve RNA and two DNA virus genera have been successfully adapted to growth at sub-optimal temperature (cold-adapted). In almost every case, there was a correlation between acquisition of the ...
Identification of sequence changes in the cold-adapted, live attenuated influenzavaccine strain, A/Ann Arbor/6/60 (H2N2)
(Elsevier, 1988-12)
Nucleotide sequences have been obtained for RNA segments encoding the 13132, P131, PA, NP, M1, M2, NS1, and NS2 proteins of the influenza A/Ann Arbor/6/60 (H2N2) wild-type (wt) virus and its cold-adapted (ca) derivative ...
Modeling and analyzing HIV transmission: the effect of contact patterns
(Elsevier, 1988-12)
A compartmental model is presented for the spread of HIV in a homosexual population divided into subgroups by degree of sexual activity. The model includes constant recruitment rates for the susceptibles in the subgroups. ...
A mutation in the PA protein gene of cold-adapted B/Ann Arbor/1/66 influenza virus associated with reversion of temperature sensitivity and attenuated virulence
(Elsevier, 1988-04)
Reassortant SG3 inherits only the acidic polymerase (PA) protein gene from the cold-adapted B/AA/1/66 influenza virus (ca B/AA/l/66) and all remaining genes from a virulent, wild-type virus. This reassortant demonstrates ...
Sequence comparison of wild-type and cold-adapted B/Ann Arbor/1/66 influenza virus genes
(Elsevier, 1988-04)
Consensus sequences for both wt and ca B/Ann Arbor/1 /66 viral PB2, PB1, PA, NP, M, and NS genes were directly determined from vRNA using a combination of chemical and chain-termination sequencing methods. There were 105 ...
The effect of cost sharing on the use of antibiotics in ambulatory care: Results from a population-based randomized controlled trial,
(Elsevier, 1987)
Little is known about how generosity of insurance and population characteristics affect quantity or appropriateness of antibiotic use. Using insurance claims for antibiotics from 5765 non-elderly people who lived in six ...
Atrial natriuretic hormone secretion in patients with renal failure
(Elsevier, 1987-09-28)
To study the effects of volume overload and renal failure on plasma levels of immunoreactive atrial natriuretic hormone (IR-ANH), we measured levels of this hormone in normal subjects, in patients with advanced chronic ...