Gammaherpesvirus-Induced Lung Pathology Is Altered in the Absence of Macrophages
dc.contributor.author | Sigler, R. E. | en_US |
dc.contributor.author | Weinberg, Jason B. | en_US |
dc.contributor.author | Rochford, Rosemary | en_US |
dc.contributor.author | Cadillac, J. M. | en_US |
dc.contributor.author | Lutzke, Mary L. | en_US |
dc.date.accessioned | 2006-09-08T19:09:25Z | |
dc.date.available | 2006-09-08T19:09:25Z | |
dc.date.issued | 2005-08 | en_US |
dc.identifier.citation | Cadillac, J. M.; Sigler, R. E.; Weinberg, J. B.; Lutzke, M. L.; Rochford, R.; (2005). "Gammaherpesvirus-Induced Lung Pathology Is Altered in the Absence of Macrophages." Lung 183(4): 239-251. <http://hdl.handle.net/2027.42/41345> | en_US |
dc.identifier.issn | 1432-1750 | en_US |
dc.identifier.issn | 0341-2040 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41345 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16211460&dopt=citation | en_US |
dc.description.abstract | The purpose of this study was to examine the lung pathogenesis of murine gammaherpesvirus (MHV-68) infection in mice that lack CC chemokine receptor CCR2, an important receptor for macrophage recruitment to sites of inflammation. BALB/c and CCR2 −/− mice were inoculated intranasally (i.n.) with MHV-68 and samples were collected during acute infection (6 dpi) and following viral clearance (12 dpi). Immunohistochemistry was used to determine which cells types responded to MHV-68 infection in the lungs. Lung pathology in infected BALB/c mice was characterized by a mixed inflammatory cell infiltrate, necrosis, and increased alveolar macrophages by 12 dpi. Immunohistochemistry showed intense positive staining for macrophages. CCR2 −/− mice showed greater inflammation in the lungs at 12 dpi than did BALB/c mice, with more necrosis and diffuse neutrophil infiltrates in the alveoli. Immunohistochemistry demonstrated much less macrophage infiltration in the CCR2 −/− mice than in the BALB/c mice. These studies show that CCR2 is involved in macrophage recruitment in response to MHV-68 infection and illustrates how impairments in macrophage function affect the normal inflammatory response to this viral infection. | en_US |
dc.format.extent | 385756 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer Science+Business Media, Inc. | en_US |
dc.subject.other | Gammaherpesvirinae/Pathogenicity | en_US |
dc.subject.other | Chemokines | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Macrophage | en_US |
dc.subject.other | Pneumology/Respiratory System | en_US |
dc.subject.other | Lung | en_US |
dc.subject.other | Disease Models, Animal | en_US |
dc.title | Gammaherpesvirus-Induced Lung Pathology Is Altered in the Absence of Macrophages | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Pediatric Infectious Diseases, University of Michigan, Ann Arbor, Michigan, 48109, USA; Kent County Health Department, M. L. Lutzke, Grand Rapids, Michigan | en_US |
dc.contributor.affiliationum | Division of Pediatric Infectious Diseases, University of Michigan, Ann Arbor, Michigan, 48109, USA | en_US |
dc.contributor.affiliationum | Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, Michigan, 48109, USA; Laboratory Animal Health Sciences, The Jackson Laboratory, 600 Main St., Bar Harbor, Maine | en_US |
dc.contributor.affiliationother | Esperion Therapeutics, Inc., 3621 S. State St., 695 KMS Place, Ann Arbor, Michigan, 48108, USA | en_US |
dc.contributor.affiliationother | Department of Microbiology and Immunology, SUNY Upstate Medical University, 750 East Adams St., Syracuse, New York, 13210, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16211460 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41345/1/408_2004_Article_2535.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00408-004-2535-y | en_US |
dc.identifier.source | Lung | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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