Prospective, multicenter study of managing lower extremity venous ulcers
dc.contributor.author | Stanley, James C. | en_US |
dc.contributor.author | Fellows, Elaine P. | en_US |
dc.contributor.author | Allen, Roger | en_US |
dc.contributor.author | Moncada, Georgia A. | en_US |
dc.contributor.author | Vickers, C. F. H. | en_US |
dc.contributor.author | Arnold, Thomas E. | en_US |
dc.contributor.author | Hutchinson, Jerry J. | en_US |
dc.contributor.author | Swartz, William M. | en_US |
dc.contributor.author | Bolton, Laura L. | en_US |
dc.contributor.author | Kerstein, Morris D. | en_US |
dc.date.accessioned | 2006-09-08T19:11:14Z | |
dc.date.available | 2006-09-08T19:11:14Z | |
dc.date.issued | 1994-07 | en_US |
dc.identifier.citation | Arnold, Thomas E.; Stanley, James C.; Fellows, Elaine P.; Moncada, Georgia A.; Allen, Roger; Hutchinson, Jerry J.; Swartz, William M.; Bolton, Laura L.; Vickers, C. F. H.; Kerstein, Morris D.; (1994). "Prospective, multicenter study of managing lower extremity venous ulcers." Annals of Vascular Surgery 8(4): 356-362. <http://hdl.handle.net/2027.42/41373> | en_US |
dc.identifier.issn | 1615-5947 | en_US |
dc.identifier.issn | 0890-5096 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41373 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7947061&dopt=citation | en_US |
dc.description.abstract | Seventy patients with 90 venous ulcers were randomly assigned to hydrocolloid or conventional dressing and compression therapy at four study centers. The ulcers had been present for a mean of 47.8 in the control and 46.2 weeks in the treatment group and 42% of all patients had recurrent ulcers. Ulcers treated with hydrocolloid dressings reduced 71% and control treated wounds reduced 43% in area after 7.2 weeks of treatment. Thirty-four percent of all ulcers healed. Mean time to healing was 7 weeks for the hydrocolloid dressing group and 8 weeks for the control group. Most ulcers were less painful at final evaluation, but reduction in pain was more pronounced in hydrocolloid-dressed ulcers ( p =0.03). At baseline as well as during follow-up, significant differences between study centers were observed. Ulcers in patients in the United Kingdom were larger and less likely to heal ( p =0.001). Size of the ulcer at baseline was associated with treatment response and time to healing ( p =0.002). Percent reduction in ulcer area after 2 weeks was also correlated with treatment outcome ( p =0.004) and time to healing ( p =0.002). When all treatment outcome predictors were analyzed together, only percent reduction in area after 2 weeks remained statistically significant ( p =0.002), with percent reduction during the first 2 weeks of treatment >30% predicting healing . | en_US |
dc.format.extent | 567095 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Annals of Vascular Surgery Inc. | en_US |
dc.subject.other | Abdominal Surgery | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.title | Prospective, multicenter study of managing lower extremity venous ulcers | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Hospital, Ann Arbor, Mich. | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Hospital, Ann Arbor, Mich. | en_US |
dc.contributor.affiliationother | Department of Surgery, Hahnemann University Medicine School, Broad and Vine streets, 19102-1192, Philadelphia, PA | en_US |
dc.contributor.affiliationother | Bristol-Myers Squibb Pharmaceuticals Ltd., Hounslow, Middlesex, UK | en_US |
dc.contributor.affiliationother | Queens Medical Centre, Nottingham, UK | en_US |
dc.contributor.affiliationother | Department of Surgery, Shadyside Hospital, Pittsburgh, Pa. | en_US |
dc.contributor.affiliationother | Department of Surgery, Shadyside Hospital, Pittsburgh, Pa. | en_US |
dc.contributor.affiliationother | Department of Surgery, Hahnemann University Medicine School, Broad and Vine streets, 19102-1192, Philadelphia, PA | en_US |
dc.contributor.affiliationother | A Division of Bristol-Myers Squibb, ConvaTec, Skillman, N.J. | en_US |
dc.contributor.affiliationother | Royal Liverpool Hospital, Liverpool, UK | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 7947061 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41373/1/10016_2005_Article_BF02132997.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02132997 | en_US |
dc.identifier.source | Annals of Vascular Surgery | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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