Gene Expression Profiles of the Rat Cochlea, Cochlear Nucleus, and Inferior Colliculus
dc.contributor.author | Cho, Younsook | en_US |
dc.contributor.author | Lomax, Margaret I. | en_US |
dc.contributor.author | Altschuler, Richard A. | en_US |
dc.contributor.author | Gong, Tzy-Wen L. | en_US |
dc.contributor.author | Stöver, Timo | en_US |
dc.date.accessioned | 2006-09-08T19:11:33Z | |
dc.date.available | 2006-09-08T19:11:33Z | |
dc.date.issued | 2002-02 | en_US |
dc.identifier.citation | Cho, Younsook; Gong, Tzy-Wen L.; Stöver, Timo; Lomax, Margaret I.; Altschuler, Richard A.; (2002). "Gene Expression Profiles of the Rat Cochlea, Cochlear Nucleus, and Inferior Colliculus." Journal of the Association for Research in Otolaryngology 3(1): 54-67. <http://hdl.handle.net/2027.42/41378> | en_US |
dc.identifier.issn | 1525-3961 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41378 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12083724&dopt=citation | en_US |
dc.description.abstract | High-throughput DNA microarray technology allows for the assessment of large numbers of genes and can reveal gene expression in a specific region, differential gene expression between regions, as well as changes in gene expression under changing experimental conditions or with a particular disease. The present study used a gene array to profile normal gene expression in the rat whole cochlea, two subregions of the cochlea (modiolar and sensorineural epithelium), and the cochlear nucleus and inferior colliculus of the auditory brainstem. The hippocampus was also assessed as a well-characterized reference tissue. Approximately 40% of the 588 genes on the array showed expression over background. When the criterion for a signal threshold was set conservatively at twice background, the number of genes above the signal threshold ranged from approximately 20% in the cochlea to 30% in the inferior colliculus. While much of the gene expression pattern was expected based on the literature, gene profiles also revealed expression of genes that had not been reported previously. Many genes were expressed in all regions while others were differentially expressed (defined as greater than a twofold difference in expression between regions). A greater number of differentially expressed genes were found when comparing peripheral (cochlear) and central nervous system regions than when comparing the central auditory regions and the hippocampus. Several families of insulin-like growth factor binding proteins, matrix metalloproteinases, and tissue inhibitor of metalloproteinases were among the genes expressed at much higher levels in the cochlea compared with the central nervous system regions. | en_US |
dc.format.extent | 851287 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Association for Research in Otolaryngology | en_US |
dc.subject.other | Gene Expression | en_US |
dc.subject.other | Gene Array | en_US |
dc.subject.other | Philosophy | en_US |
dc.subject.other | Inferior Colliculus | en_US |
dc.subject.other | Hippocampus | en_US |
dc.subject.other | DNA Microarray | en_US |
dc.subject.other | Cochlea | en_US |
dc.subject.other | Cochlear Nucleus | en_US |
dc.title | Gene Expression Profiles of the Rat Cochlea, Cochlear Nucleus, and Inferior Colliculus | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head-Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Otolaryngology, Medical University of Hannover, Hannover, Germany | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Kresge Hearing Research Institute, Department of Otolaryngology/Head-Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, Department of Otolaryngology/Head-Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Kresge Hearing Research Institute, Department of Otolaryngology/Head-Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Kresge Hearing Research Institute, Department of Otolaryngology/Head-Neck Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12083724 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41378/1/10162_2000_Article_42.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s101620010042 | en_US |
dc.identifier.source | Journal of the Association for Research in Otolaryngology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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