Disruption of Lateral Efferent Pathways: Functional Changes in Auditory Evoked Responses
dc.contributor.author | Shore, Susan E. | en_US |
dc.contributor.author | Hughes, Larry F. | en_US |
dc.contributor.author | Prell, Colleen G. | en_US |
dc.contributor.author | Bledsoe, Sanford C., Jr. | en_US |
dc.date.accessioned | 2006-09-08T19:11:37Z | |
dc.date.available | 2006-09-08T19:11:37Z | |
dc.date.issued | 2003-06 | en_US |
dc.identifier.citation | Prell, Colleen G.; Shore, Susan E.; Hughes, Larry F.; Bledsoe, Sanford C.; (2003). "Disruption of Lateral Efferent Pathways: Functional Changes in Auditory Evoked Responses." Journal of the Association for Research in Otolaryngology 4(2): 276-290. <http://hdl.handle.net/2027.42/41379> | en_US |
dc.identifier.issn | 1525-3961 | en_US |
dc.identifier.issn | 1438-7573 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41379 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12943378&dopt=citation | en_US |
dc.description.abstract | The functional consequences of selectively lesioning the lateral olivocochlear efferent system in guinea pigs were studied. The lateral superior olive (LSO) contains the cell bodies of lateral olivocochlear neurons. Melittin, a cytotoxic chemical, was injected into the brain stem using stereotaxic coordinates and near-field evoked potentials to target the LSO. Brain stem histology revealed discrete damage to the LSO following the injections. Functional consequences of this damage were reflected in depressed amplitude of the compound action potential of the eighth nerve (CAP) following the lesion. Threshold sensitivity and N1 latencies were relatively unchanged. Onset adaptation of the cubic distortion product otoacoustic emission (DPOAE) was evident, suggesting a reasonably intact medial efferent system. The present results provide the first report of functional changes induced by isolated manipulation of the lateral efferent pathway. They also confirm the suggestion that changes in single-unit auditory nerve activity after cutting the olivocochlear bundle are probably a consequence of disrupting the more lateral of the two olivocochlear efferent pathways. | en_US |
dc.format.extent | 378966 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Association for Research in Otolaryngology | en_US |
dc.subject.other | Guinea Pig | en_US |
dc.subject.other | Olivocochlear | en_US |
dc.subject.other | Lateral Superior Olive | en_US |
dc.subject.other | Philosophy | en_US |
dc.subject.other | Compound Action Potential | en_US |
dc.subject.other | Distortion Product Otoacoustic Emission | en_US |
dc.title | Disruption of Lateral Efferent Pathways: Functional Changes in Auditory Evoked Responses | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109-0506, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109-0506, USA | en_US |
dc.contributor.affiliationum | Kresge Hearing Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109-0506, USA | en_US |
dc.contributor.affiliationother | Center for Alzheimer Disease and Related Disorders, Southern Illinois University Medical School, Springfield, IL 62702, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12943378 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41379/1/10162_2002_Article_3018.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s10162-002-3018-6 | en_US |
dc.identifier.source | Journal of the Association for Research in Otolaryngology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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