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Intratumoral IL-12 and TNF-α–Loaded Microspheres Lead To Regression of Breast Cancer and Systemic Antitumor Immunity
dc.contributor.authorChang, Wen-Jianen_US
dc.contributor.authorBailey, Nicolaen_US
dc.contributor.authorSabel, Michael S.en_US
dc.contributor.authorChang, Alfred E.en_US
dc.contributor.authorMathiowitz, Edithen_US
dc.contributor.authorEgilmez, Nejat K.en_US
dc.contributor.authorStoolman, Lloyd M.en_US
dc.contributor.authorSkitzki, Josephen_US
dc.date.accessioned2006-09-08T19:13:05Z
dc.date.available2006-09-08T19:13:05Z
dc.date.issued2004-01en_US
dc.identifier.citationSabel, Michael S.; Skitzki, Joseph; Stoolman, Lloyd; Egilmez, Nejat K.; Mathiowitz, Edith; Bailey, Nicola; Chang, Wen-Jian; Chang, Alfred E.; (2004). "Intratumoral IL-12 and TNF-α–Loaded Microspheres Lead To Regression of Breast Cancer and Systemic Antitumor Immunity." Annals of Surgical Oncology 11(2): 147-156. <http://hdl.handle.net/2027.42/41401>en_US
dc.identifier.issn1068-9265en_US
dc.identifier.issn1534-4681en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41401
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=14761917&dopt=citationen_US
dc.description.abstractBackground: Local, sustained delivery of cytokines at a tumor can enhance induction of antitumor immunity and may be a feasible neoadjuvant immunotherapy for breast cancer. We evaluated the ability of intratumoral poly-lactic-acid-encapsulated microspheres (PLAM) containing interleukin 12 (IL-12), tumor necrosis factor α (TNF-α), and granulocyte-macrophage colony stimulating factor (GM-CSF) in a murine model of breast cancer to generate a specific antitumor response.en_US
dc.format.extent363064 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; The Society of Surgical Oncology, Inc.en_US
dc.subject.otherSurgical Oncologyen_US
dc.subject.otherIL-12en_US
dc.subject.otherSurgeryen_US
dc.subject.otherMicrospheresen_US
dc.subject.otherOncologyen_US
dc.subject.otherBreast Canceren_US
dc.subject.otherMedicine & Public Healthen_US
dc.subject.otherTNF-αen_US
dc.subject.otherImmunotherapyen_US
dc.titleIntratumoral IL-12 and TNF-α–Loaded Microspheres Lead To Regression of Breast Cancer and Systemic Antitumor Immunityen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelSurgery and Anesthesiologyen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDivision of Surgical Oncology, University of Michigan, Ann Arbor, Michigan; Division of Surgical Oncology, University of Michigan Comprehensive Cancer Center, 3304 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI, 48109–0932en_US
dc.contributor.affiliationumDivision of Surgical Oncology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDivision of Surgical Oncology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDivision of Surgical Oncology, University of Michigan, Ann Arbor, Michiganen_US
dc.contributor.affiliationotherBrown University, Providence, Rhode, Islanden_US
dc.contributor.affiliationotherSUNY at Buffalo, Buffalo, New Yorken_US
dc.contributor.affiliationotherBrown University, Providence, Rhode, Islanden_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid14761917en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41401/1/10434_2004_Article_147.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1245/ASO.2004.03.022en_US
dc.identifier.sourceAnnals of Surgical Oncologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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