View Item 

Show simple item record

Estimation of the Increase in Solubility of Drugs as a Function of Bile Salt Concentration

dc.contributor.authorMithani, Sabena D.en_US
dc.contributor.authorBakatselou, Vassilikien_US
dc.contributor.authorDressman, Jennifer B.en_US
dc.contributor.authorTenHoor, Christopher N.en_US
dc.date.accessioned2006-09-08T19:16:04Z
dc.date.available2006-09-08T19:16:04Z
dc.date.issued1996-01en_US
dc.identifier.citationMithani, Sabena D.; Bakatselou, Vassiliki; TenHoor, Christopher N.; Dressman, Jennifer B.; (1996). "Estimation of the Increase in Solubility of Drugs as a Function of Bile Salt Concentration." Pharmaceutical Research 13(1): 163-167. <http://hdl.handle.net/2027.42/41447>en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41447
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8668668&dopt=citationen_US
dc.description.abstractPurpose . The objective of this study was to develop a model to predict the extent to which bile salts can enhance the solubility of a drug, based on the physicochemical properties of the compound. The ability to predict bile salt solubilization of poorly soluble drugs would be a key component in determining which drugs will exhibit fed vs. fasted differences in drug absorption.en_US
dc.format.extent976719 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherPharmacyen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherPoorly Soluble Drugsen_US
dc.subject.otherSolubilityen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherSodium Taurocholateen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherBile Saltsen_US
dc.subject.otherPartition Coefficienten_US
dc.titleEstimation of the Increase in Solubility of Drugs as a Function of Bile Salt Concentrationen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065; Janssen Pharmaceuticals, Athens, Greeceen_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065; Hoechst-Roussel Pharmaceuticals, Somerville, New Jersey, 08801en_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065; Johann Wolfang Goethe-Universitat, Biozentrum, D-60439, Frankfurt am Main, Germanyen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid8668668en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41447/1/11095_2004_Article_306524.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1016062224568en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
11095_2004_Article_306524.pdf
Size:
953.8KB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.