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Effect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skin

dc.contributor.authorLi, Wen Y.en_US
dc.contributor.authorKoda, Robert T.en_US
dc.contributor.authorChatterjee, Dhruba J.en_US
dc.date.accessioned2006-09-08T19:16:53Z
dc.date.available2006-09-08T19:16:53Z
dc.date.issued1997-08en_US
dc.identifier.citationChatterjee, Dhruba J.; Li, Wen Y.; Koda, Robert T.; (1997). "Effect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skin." Pharmaceutical Research 14(8): 1058-1065. <http://hdl.handle.net/2027.42/41459>en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41459
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9279889&dopt=citationen_US
dc.description.abstractPurpose . Low-dose methotrexate (MTX) is approved for the treatment of recalcitrant rheumatoid arthritis (RA). The objective of this study was to determine the effect of vehicles and penetration enhancers on the percutaneous absorption of MTX and its analog edatrexate (EDAM), and develop transdermal (TD) delivery systems of the drugs for the treatment of RA.en_US
dc.format.extent676527 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherPharmacyen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherEdatrexateen_US
dc.subject.otherMethotrexateen_US
dc.subject.otherTransdermalen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherPercutaneousen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherRheumatoid Arthritisen_US
dc.titleEffect of Vehicles and Penetration Enhancers on the In Vitro and In Vivo Percutaneous Absorption of Methotrexate and Edatrexate Through Hairless Mouse Skinen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy Rm. 2059, University of Michigan, 428 Church Street, Ann Arbor, Michigan, 48109en_US
dc.contributor.affiliationotherSchool of Pharmacy, Rm 200C, University of Southern California, 1985 Zonal Avenue, Los Angeles, California, 90033en_US
dc.contributor.affiliationotherSchool of Pharmacy, Rm 200C, University of Southern California, 1985 Zonal Avenue, Los Angeles, California, 90033en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid9279889en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41459/1/11095_2004_Article_304264.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1012109513643en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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