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5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT Are Absorbed by the Intestinal PEPT1 Peptide Transporter
dc.contributor.authorOh, Doo-Manen_US
dc.contributor.authorRhie, Julie K.en_US
dc.contributor.authorSmith, Philip L.en_US
dc.contributor.authorLee, Chao-Pinen_US
dc.contributor.authorAmidon1, Gordon L.en_US
dc.contributor.authorSadee, Wolfgangen_US
dc.contributor.authorHan, Hyo-kyungen_US
dc.contributor.authorde Vrueh, Remco L. A.en_US
dc.contributor.authorCovitz, Kuang-Ming Y.en_US
dc.date.accessioned2006-09-08T19:17:20Z
dc.date.available2006-09-08T19:17:20Z
dc.date.issued1998-08en_US
dc.identifier.citationHan, Hyo-kyung; de Vrueh, Remco L. A.; Rhie, Julie K.; Covitz, Kuang-Ming Y.; Smith, Philip L.; Lee, Chao-Pin; Oh, Doo-Man; Sadee, Wolfgang; Amidon1, Gordon L.; (1998). "5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT Are Absorbed by the Intestinal PEPT1 Peptide Transporter." Pharmaceutical Research 15(8): 1154-1159. <http://hdl.handle.net/2027.42/41466>en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41466
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9706043&dopt=citationen_US
dc.description.abstractPurpose . General use of nucleoside analogues in the treatment of viral infections and cancer is often limited by poor oral absorption. Valacyclovir, a water soluble amino acid ester prodrug of acyclovir has been reported to increase the oral bioavailability of acyclovir but its absorption mechanism is unknown. This study characterized the intestinal absorption mechanism of 5′-amino acid ester prodrugs of the antiviral drugs and examined the potential of amino acid esters as an effective strategy for improving oral drug absorption.en_US
dc.format.extent500951 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherPermeabilityen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.subject.otherPEPT1 Transporteren_US
dc.subject.otherBiomedicineen_US
dc.subject.otherProdrugsen_US
dc.subject.otherAmino Acid Esteren_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherPharmacyen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherMedical Lawen_US
dc.title5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT Are Absorbed by the Intestinal PEPT1 Peptide Transporteren_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065; NIH-NIGMS/FDA-CBER-DCGT, Bethesda, Maryland, 20892en_US
dc.contributor.affiliationumCollege of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065en_US
dc.contributor.affiliationotherDepartment of Biopharmaceutical Sciences and Pharmaceutical Chemistry, University of California, San Francisco, Californiaen_US
dc.contributor.affiliationotherDivision of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlandsen_US
dc.contributor.affiliationotherDepartment of Drug Delivery, Pharmaceutical Technologies, Smith-Kline Beecham Pharmaceuticals, Collegeville, Pennsylvania, 19426-0989en_US
dc.contributor.affiliationotherDepartment of Biopharmaceutical Sciences and Pharmaceutical Chemistry, University of California, San Francisco, Californiaen_US
dc.contributor.affiliationotherDepartment of Drug Delivery, Pharmaceutical Technologies, Smith-Kline Beecham Pharmaceuticals, Collegeville, Pennsylvania, 19426-0989en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid9706043en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41466/1/11095_2004_Article_303953.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1011919319810en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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