Targeting and Blocking B7 Costimulatory Molecules on Antigen-Presenting Cells Using CTLA4Ig-Conjugated Liposomes: In Vitro Characterization and in Vivo Factors Affecting Biodistribution
dc.contributor.author | Park, Chung-Gyu | en_US |
dc.contributor.author | Thiex, Natalie W. | en_US |
dc.contributor.author | Lee, Kyung-Dall | en_US |
dc.contributor.author | Bluestone, Jeffery A. | en_US |
dc.contributor.author | Szot, Gregory L. | en_US |
dc.contributor.author | Lee, Kyung-Mi | en_US |
dc.date.accessioned | 2006-09-08T19:19:34Z | |
dc.date.available | 2006-09-08T19:19:34Z | |
dc.date.issued | 2003-08 | en_US |
dc.identifier.citation | Park, Chung-Gyu; Thiex, Natalie W.; Lee, Kyung-Mi; Szot, Gregory L.; Bluestone, Jeffery A.; Lee, Kyung-Dall; (2003). "Targeting and Blocking B7 Costimulatory Molecules on Antigen-Presenting Cells Using CTLA4Ig-Conjugated Liposomes: In Vitro Characterization and in Vivo Factors Affecting Biodistribution." Pharmaceutical Research 20(8): 1239-1248. <http://hdl.handle.net/2027.42/41500> | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41500 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12948022&dopt=citation | en_US |
dc.description.abstract | Purpose. CTLA4Ig, a fusion protein of CTLA-4 and Fc of immunoglobulin (Ig) heavy chain, inhibits the essential costimulatory signal for full T cell activation via blocking the interaction between CD28 and B7 molecules and renders T cell nonresponsiveness. CTLA4Ig has been used to control deleterious T cell activation in many experimental systems. We hypothesized that by conjugating CTLA4Ig to liposomes the efficacy of CTLA4Ig could be enhanced through multivalent ligand effect, superior targetability, and modification of the fate of ligated costimulatory molecules. | en_US |
dc.format.extent | 166335 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Islet Transplantation | en_US |
dc.subject.other | CTLA4Ig | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | B7 Costimulatory Molecules | en_US |
dc.subject.other | Targeting | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Liposomes | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Medical Law | en_US |
dc.title | Targeting and Blocking B7 Costimulatory Molecules on Antigen-Presenting Cells Using CTLA4Ig-Conjugated Liposomes: In Vitro Characterization and in Vivo Factors Affecting Biodistribution | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065; UCSF Diabetes Center, University of California, San Francisco, California, 94143-0540; Department of Microbiology and Immunology, The Transplantation Research Institute, Seoul National University College of Medicine, Seoul, 110-799, Korea | en_US |
dc.contributor.affiliationum | Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, 48109-1065 | en_US |
dc.contributor.affiliationother | UCSF Diabetes Center, University of California, San Francisco, California, 94143-0540 | en_US |
dc.contributor.affiliationother | UCSF Diabetes Center, University of California, San Francisco, California, 94143-0540 | en_US |
dc.contributor.affiliationother | UCSF Diabetes Center, University of California, San Francisco, California, 94143-0540 | en_US |
dc.contributor.affiliationother | The Committee on Immunology, Department of Pathology, University of Chicago, Chicago, Illinois, 60637 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12948022 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41500/1/11095_2004_Article_468685.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1025057216492 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.