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Liposomal Formulations of Inflammatory Bowel Disease Drugs: Local versus Systemic Drug Delivery in a Rat Model

dc.contributor.authorFleisher, Daviden_US
dc.contributor.authorZhou, Simon Yujien_US
dc.contributor.authorZimmermann, Ellen M.en_US
dc.contributor.authorKesisoglou, Filipposen_US
dc.contributor.authorNiemiec, Susan M.en_US
dc.contributor.authorLee, Jordan Wingen_US
dc.date.accessioned2006-09-08T19:20:09Z
dc.date.available2006-09-08T19:20:09Z
dc.date.issued2005-08en_US
dc.identifier.citationKesisoglou, Filippos; Zhou, Simon Yuji; Niemiec, Susan; Lee, Jordan Wing; Zimmermann, Ellen M.; Fleisher, David; (2005). "Liposomal Formulations of Inflammatory Bowel Disease Drugs: Local versus Systemic Drug Delivery in a Rat Model." Pharmaceutical Research 22(8): 1320-1330. <http://hdl.handle.net/2027.42/41509>en_US
dc.identifier.issn0724-8741en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41509
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16078142&dopt=citationen_US
dc.description.abstractBased on adherence to intestinal mucosa, intralumenally administered liposomal formulations of 5-aminosalicylate (5-ASA) and 6-mercaptopurine (6-MP) were studied for their potential to enhance local drug delivery to intestinal tissue for the treatment of inflammatory bowel disease.en_US
dc.format.extent377939 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Springer Science + Business Media, Inc.en_US
dc.subject.otherBiomedicineen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherLiposomesen_US
dc.subject.otherIntestineen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherDrug Deliveryen_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherInflammatory Bowel Diseaseen_US
dc.subject.otherAbsorptionen_US
dc.subject.otherPharmacyen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.titleLiposomal Formulations of Inflammatory Bowel Disease Drugs: Local versus Systemic Drug Delivery in a Rat Modelen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065, USA; Division of Gastroenterology, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan, 48109-0682, USAen_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065, USAen_US
dc.contributor.affiliationumDivision of Gastroenterology, Department of Internal Medicine, The University of Michigan, Ann Arbor, Michigan, 48109-0682, USAen_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065, USAen_US
dc.contributor.affiliationumDepartment of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109-1065, USAen_US
dc.contributor.affiliationotherPfizer Global Research and Development, Ann Arbor Laboratories, Ann Arbor, Michigan, 48105, USAen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid16078142en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41509/1/11095_2005_Article_5376.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s11095-005-5376-3en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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