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Radioiodinated Cholesteryl lopanoate as a Potential Probe for the in Vivo Visualization of Atherosclerotic Lesions in Animals
dc.contributor.authorWeichert, Jamey P.en_US
dc.contributor.authorGalan, Mark R.en_US
dc.contributor.authorCounsell, Raymond E.en_US
dc.contributor.authorSchwendner, Susan W.en_US
dc.date.accessioned2006-09-08T19:20:17Z
dc.date.available2006-09-08T19:20:17Z
dc.date.issued1986-02en_US
dc.identifier.citationGalan, Mark R.; Schwendner, Susan W.; Weichert, Jamey P.; Counsell, Raymond E.; (1986). "Radioiodinated Cholesteryl lopanoate as a Potential Probe for the in Vivo Visualization of Atherosclerotic Lesions in Animals." Pharmaceutical Research 3(1): 52-55. <http://hdl.handle.net/2027.42/41511>en_US
dc.identifier.issn1573-904Xen_US
dc.identifier.issn0724-8741en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41511
dc.description.abstractRadioiodinated cholesteryl iopanoate, a nonhydrolyzable cholesteryl ester probe, showed increased uptake into atherosclerotic aortas of cholesterol-fed rabbits in comparison with normal rabbits. Auto-radiography of the aortas showed the radioactivity to be concentrated in areas of visible atherosclerotic involvement. Lipid extraction and thin-layer chromatography of this tissue as well as liver, adrenal, and plasma confirmed the resistance of this probe to hydrolysis. These findings suggest that 125 I-cholesteryl iopanoate may prove useful for noninvasively monitoring atherosclerosis in intact laboratory animals.en_US
dc.format.extent1006202 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherKluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Mediaen_US
dc.subject.otherBiomedicineen_US
dc.subject.otherRadioiodinated Cholesteryl Iopanoateen_US
dc.subject.otherBiomedical Engineeringen_US
dc.subject.otherRabbiten_US
dc.subject.otherBiochemistry, Generalen_US
dc.subject.otherNonhydrolyzable Cholesteryl Ester Probeen_US
dc.subject.otherMedical Lawen_US
dc.subject.otherAtherosclerosisen_US
dc.subject.otherPharmacyen_US
dc.subject.otherPharmacology/Toxicologyen_US
dc.titleRadioiodinated Cholesteryl lopanoate as a Potential Probe for the in Vivo Visualization of Atherosclerotic Lesions in Animalsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, 48109-0010en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, 48109-0010en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, 48109-0010en_US
dc.contributor.affiliationumDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, 48109-0010en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid24271358en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41511/1/11095_2004_Article_306434.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1023/A:1016376916448en_US
dc.identifier.sourcePharmaceutical Researchen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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