Dissolution of lonizable Drugs in Buffered and Unbuffered Solutions
dc.contributor.author | Ozturk, Sadettin S. | en_US |
dc.contributor.author | Dressman, Jennifer B. | en_US |
dc.contributor.author | Palsson, Bernhard Ø | en_US |
dc.date.accessioned | 2006-09-08T19:21:04Z | |
dc.date.available | 2006-09-08T19:21:04Z | |
dc.date.issued | 1988-05 | en_US |
dc.identifier.citation | Ozturk, Sadettin S.; Palsson, Bernhard O.; Dressman, Jennifer B.; (1988). "Dissolution of lonizable Drugs in Buffered and Unbuffered Solutions." Pharmaceutical Research 5(5): 272-282. <http://hdl.handle.net/2027.42/41523> | en_US |
dc.identifier.issn | 1573-904X | en_US |
dc.identifier.issn | 0724-8741 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41523 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3244637&dopt=citation | en_US |
dc.description.abstract | The dissolution kinetics of ionizable drugs (weak acids or bases) are analyzed with a mathematical model derived from the theory of mass transfer with chemical reaction. The model assumes that the overall process is diffusion limited, that all the reactions are reversible and instantaneous, and that dissolution and reaction are limited to the stagnant fluid film adjacent to the solid phase. Dissolution into buffered and unbuffered aqueous solutions are considered separately, with covenient analytical solutions obtained in both cases. In addition, equations for the time to partial and complete dissolution are derived. The dissolution rate is shown to be dependent on the p K a and intrinsic solubility and the medium properties, i.e., pH, buffer capacity, and mass transfer coefficient. Equations of a form analogous to the nonionized case are derived to account explicitly for all these factors, with dissolution rates expressed in terms of the product of a driving force (concentration difference) and resistance (inverse of mass transfer coefficient). The solutions are in an accessible analytical form to calculate the surface pH and subsequently the surface concentrations driving the drug dissolution. Numerical examples to illustrate dissolution into unbuffered and buffered media are presented and the results are shown to be in accord with experimental data taken from the literature. | en_US |
dc.format.extent | 1607325 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media | en_US |
dc.subject.other | Medical Law | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Drug Dissolution | en_US |
dc.subject.other | Ionization and Dissolution | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Film Model for Dissolution | en_US |
dc.subject.other | Biochemistry, General | en_US |
dc.subject.other | Pharmacy | en_US |
dc.subject.other | Buffer Effect on Dissolution | en_US |
dc.title | Dissolution of lonizable Drugs in Buffered and Unbuffered Solutions | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | College of Pharmacy, The University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationum | Department of Chemical Engineering, The University of Michigan, Ann Arbor, Michigan, 48109 | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3244637 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41523/1/11095_2004_Article_306188.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1023/A:1015970502993 | en_US |
dc.identifier.source | Pharmaceutical Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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