Immunity in dilated cardiomyopathy
dc.contributor.author | Cassidy, James T. | en_US |
dc.contributor.author | Huber, Sally A. | en_US |
dc.contributor.author | Das, Sunil K. | en_US |
dc.date.accessioned | 2006-09-08T19:25:04Z | |
dc.date.available | 2006-09-08T19:25:04Z | |
dc.date.issued | 1985-03 | en_US |
dc.identifier.citation | Das, Sunil K.; Cassidy, James T.; Huber, Sally A.; (1985). "Immunity in dilated cardiomyopathy." Heart and Vessels 1(1): 205-208. <http://hdl.handle.net/2027.42/41584> | en_US |
dc.identifier.issn | 0910-8327 | en_US |
dc.identifier.issn | 1615-2573 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41584 | |
dc.description.abstract | Although several immunologic parameters have been found to be abnormal, their precise relationship to the cause of the disease remains unclear. It is believed that a virus initiating a bout of myocarditis may play a role in the perpetuation of the chronic phase, probably via immunologic mediation. A selection acquired defect or damage to a subpopulation of suppressor T lymphocytes is possible, providing the basis for the development of an autoimmune disorder. Studies in mice have shown a clear link between active viral myocarditis and the subsequent development of cardiomyopathy. However, the trigger mechanism that initiates the cardiomyopathy is still elusive. Specific antigens, possibly altered virus or damaged cardiac tissue, may be playing the role of the “hidden or cloistered” antigen in eliciting the immunologic reactions through a cytotoxic T-cell mechanism. Identification and isolation of the specific “antigen” in question could resolve the dilemmas about the immunopathogenesis of cardiomyopathy in humans. | en_US |
dc.format.extent | 679516 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Biomedical Engineering | en_US |
dc.subject.other | Cardiac Surgery | en_US |
dc.subject.other | Ultrasound | en_US |
dc.subject.other | Cardiology | en_US |
dc.subject.other | Interventional Radiology | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Vascular Surgery | en_US |
dc.title | Immunity in dilated cardiomyopathy | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, The University of Michigan Medical School, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, The University of Vermont Medical College, Burlington, Vermont, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41584/1/380_2005_Article_BF02072394.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF02072394 | en_US |
dc.identifier.source | Heart and Vessels | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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