The North American Multiple System Atrophy Study Group
dc.contributor.author | Gilman, Sid | en_US |
dc.contributor.author | Trojanowski, John Q. | en_US |
dc.contributor.author | Ozelius, Laurie J. | en_US |
dc.contributor.author | Shults, Clifford W. | en_US |
dc.contributor.author | Low, Phillip A. | en_US |
dc.contributor.author | Foroud, Tatiana | en_US |
dc.contributor.author | Masliah, E. | en_US |
dc.contributor.author | Sandroni, Paola | en_US |
dc.contributor.author | Lee, Virginia M-Y. | en_US |
dc.contributor.author | Tanner, Caroline M. | en_US |
dc.contributor.author | Kukull, W. | en_US |
dc.contributor.author | May, S. J. | en_US |
dc.date.accessioned | 2006-09-08T19:29:32Z | |
dc.date.available | 2006-09-08T19:29:32Z | |
dc.date.issued | 2005-12 | en_US |
dc.identifier.citation | Gilman, S.; May, S. J.; Shults, C. W.; Tanner, C. M.; Kukull, W.; Lee, V. M.-Y.; Masliah, E.; Low, P.; Sandroni, P.; Trojanowski, J. Q.; Ozelius, L.; Foroud, T.; (2005). "The North American Multiple System Atrophy Study Group." Journal of Neural Transmission 112(12): 1687-1694. <http://hdl.handle.net/2027.42/41653> | en_US |
dc.identifier.issn | 1435-1463 | en_US |
dc.identifier.issn | 0300-9564 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41653 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=16284910&dopt=citation | en_US |
dc.description.abstract | The North American Multiple System Atrophy Study Group involves investigators in 12 US medical centers funded by a grant from the National Institutes of Health. The objectives are to examine the environmental and genetic risk factors for MSA; elucidate pathogenic mechanisms underlying the disorder; and refine evaluations used for assessment. During its first year, the group enrolled 87 patients, implemented four cores, and initiated four scientific projects. Most patients among the 87 had parkinsonian features, which frequently began asymmetrically and remained asymmetrical; one-third responded to levodopa and many developed levodopa complications; almost two-thirds of the patients had cerebellar dysfunction, of these 90% had ataxia; urinary incontinence occurred commonly, and sleep disorders affected most. The investigators studied the effects of oxidative and nitrative stress upon the formation of alpha-synuclein inclusions; generated transgenic models of alpha-synuclein accumulation that recapitulate several behavioral and neuropathological features of MSA; and compared the severity of the autonomic features of MSA, Parkinson’s disease and dementia with Lewy bodies. | en_US |
dc.format.extent | 64157 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag/Wien | en_US |
dc.subject.other | Medicine & Public Health | en_US |
dc.subject.other | Psychiatry | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Pharmacology/Toxicology | en_US |
dc.subject.other | Keywords: Multiple System Atrophy, Parkinsonism, Cerebellar Ataxia, Autonomic Failure. | en_US |
dc.title | The North American Multiple System Atrophy Study Group | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbsecondlevel | Psychology | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, , University of Michigan, Ann Arbor, MI, USA, | en_US |
dc.contributor.affiliationother | Department of Pathology & Laboratory Medicine, Center on Neurological Disease Research, , University of Pennsylvania, Philadelphia, PA, USA, | en_US |
dc.contributor.affiliationother | Department of Neurology, , Mayo Clinic, Rochester, MA, USA, | en_US |
dc.contributor.affiliationother | Department of Epidemiology, , University of Washington, Seattle, WA, USA, | en_US |
dc.contributor.affiliationother | Department of Molecular Genetics, , Albert Einstein College of Medicine, Bronx, NY, USA, | en_US |
dc.contributor.affiliationother | Department of Medicine and Molecular Genetics, , Indiana University School of Medicine, Indianapolis, IN, USA, | en_US |
dc.contributor.affiliationother | Department of Pathology & Laboratory Medicine, Center on Neurological Disease Research, , University of Pennsylvania, Philadelphia, PA, USA, | en_US |
dc.contributor.affiliationother | VA San Diego Healthcare System, San Diego, CA, USA, ; Department of Neurosciences, , University of California, San Diego, La Jolla, CA, USA, | en_US |
dc.contributor.affiliationother | Department of Family & Preventive Medicine, , University of California San Diego, La Jolla, CA, USA, ; Department of Neurosciences, , University of California, San Diego, La Jolla, CA, USA, | en_US |
dc.contributor.affiliationother | Department of Neurology, , Mayo Clinic, Rochester, MA, USA, | en_US |
dc.contributor.affiliationother | Department of Clinical Research, , Parkinson’s Institute, Sunnyvale, CA, USA, | en_US |
dc.contributor.affiliationother | Department of Neurosciences, , University of California, San Diego, La Jolla, CA, USA, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 16284910 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41653/1/702_2005_Article_381.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00702-005-0381-6 | en_US |
dc.identifier.source | Journal of Neural Transmission | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.