Nucleo-cytoplasmic studies in the development of influenza virus in mammalian cells
dc.contributor.author | Bell, William C. | en_US |
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.date.accessioned | 2006-09-08T19:31:11Z | |
dc.date.available | 2006-09-08T19:31:11Z | |
dc.date.issued | 1969-06 | en_US |
dc.identifier.citation | Bell, W. C.; Maassab, H. F.; (1969). "Nucleo-cytoplasmic studies in the development of influenza virus in mammalian cells." Archiv für die gesamte Virusforschung 27 (2-4): 128-137. <http://hdl.handle.net/2027.42/41679> | en_US |
dc.identifier.issn | 0304-8608 | en_US |
dc.identifier.issn | 1432-8798 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41679 | |
dc.description.abstract | A non-ionic detergent method of cell fractionation was used to follow the time course of tritiated uridine incorporation into influenza A-NWS virus-induced RNA in a continuous mammalian cell line. The maximum incorporation of tritiated uridine into acid-insoluble RNA of nuclear fractions occurred at 2 to 2.5 hours post infection. A maximum of labelled acid-insoluble RNA of the cytoplasmic fractions was found at 3 to 4 hours post infection which coincided with active synthesis of infectious virus. The effect of influenza A-NWS infection on the rate of tritiated thymidine incorporation into acid-insoluble DNA was found to be an initial depression 1 to 2 hours post infection followed by recovery to near normal values, then a gradual decline until at 8 hours post infection it was approximately 60% of that shown by the control cell cultures. | en_US |
dc.format.extent | 790551 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Infectious Diseases | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Virology | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.title | Nucleo-cytoplasmic studies in the development of influenza virus in mammalian cells | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Virus Laboratory, Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationum | Virus Laboratory, Department of Epidemiology, School of Public Health, The University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41679/1/705_2005_Article_BF01249638.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01249638 | en_US |
dc.identifier.source | Archiv für die gesamte Virusforschung | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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