Cold adapted variants of influenza A
dc.contributor.author | Spring, S. B. | en_US |
dc.contributor.author | Murphy, Brian R. | en_US |
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.contributor.author | Chanock, Robert M. | en_US |
dc.contributor.author | Kendal, Alan P. | en_US |
dc.date.accessioned | 2006-09-08T19:31:33Z | |
dc.date.available | 2006-09-08T19:31:33Z | |
dc.date.issued | 1977-09 | en_US |
dc.identifier.citation | Spring, S. B.; Maassab, H. F.; Kendal, A. P.; Murphy, B. R.; Chanock, R. M.; (1977). "Cold adapted variants of influenza A." Archives of Virology 55(3): 233-246. <http://hdl.handle.net/2027.42/41685> | en_US |
dc.identifier.issn | 0304-8608 | en_US |
dc.identifier.issn | 1432-8798 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41685 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=597038&dopt=citation | en_US |
dc.description.abstract | The genetic and biological properties of 13 recombinant influenza A clones derived at 25°C from the A/AA/6/60-cold variant (by crosses with 4 different wild type strains) were compared with a set of 5-FU induced ts -mutants. The 5-FU mutants had previously been placed into 7 complementation-recombination groups; the A/AA/6/60-cold parent (PI-7) and the 12 cold recombinant clones which were ts were shown to share a lesion with only one of these groups. The parental strain and 5 recombinant clones were evaluated for replication in the lungs and nasal turbinates of hamsters. Each virus appeared to be attenuated; genetic stability correlated with the level of viral replication in the hamster lung, i.e., viruses which grew best showed a tendency to revert to the ts + phenotype. Characterization of the ts + revertants for the presence of the cold adaptation property revealed that these viruses exhibited a spectrum of cold adaptation properties. Two viruses, PI-7 (the parental cold variant) and the CR6 recombinant (A/Queensland/6/72) did not revert in either the lungs or nasal turbinates of hamsters. | en_US |
dc.format.extent | 1163141 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Infectious Diseases | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Virology | en_US |
dc.title | Cold adapted variants of influenza A | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. | en_US |
dc.contributor.affiliationother | Respiratory Virology Branch, Bureau of Laboratories, Center for Disease Control, Atlanta, Georgia, U.S.A. | en_US |
dc.contributor.affiliationother | Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, U.S.A. | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 597038 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41685/1/705_2005_Article_BF01319909.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01319909 | en_US |
dc.identifier.source | Archives of Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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