Influenza virus infection of newborn rats: Virulence of recombinant strains prepared from a cold-adapted, attenuated parent
dc.contributor.author | Jennings, R. | en_US |
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.contributor.author | Mahmud, M. I. A. | en_US |
dc.contributor.author | Potter, C. W. | en_US |
dc.date.accessioned | 2006-09-08T19:31:40Z | |
dc.date.available | 2006-09-08T19:31:40Z | |
dc.date.issued | 1979-09 | en_US |
dc.identifier.citation | Mahmud, M. I. A.; Maassab, H. F.; Jennings, R.; Potter, C. W.; (1979). "Influenza virus infection of newborn rats: Virulence of recombinant strains prepared from a cold-adapted, attenuated parent." Archives of Virology 61(3): 207-216. <http://hdl.handle.net/2027.42/41687> | en_US |
dc.identifier.issn | 1432-8798 | en_US |
dc.identifier.issn | 0304-8608 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41687 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=496643&dopt=citation | en_US |
dc.description.abstract | Infant rats were infected with one of a series of influenza A viruses. The growth of viruses in the turbinates or lungs, and the ability of virus infection to potentiate a subsequent bacterial infection by Haemophilus influenzae (HIb), were measured. The three virus strains known to be virulent for man grew to relatively high titres-of 10 5.0 –10 6.8 EBID 50 /ml in the turbinates of infant rats at 48 hours post-infection, and virus infection enhanced subsequent systemic infection following intranasal inoculation of rats with HIb. In contrast, influenza virus A/Ann Arbor/6/60—P17 and the three recombinant viruses prepared from this strain, all of which are attenuated for man, replicated to significantly lower titres of 10 2.6 –10 4.1 EBID 50 /ml in infant rats turbinates, and failed to promote systemic infection by HIb to the same degree. The results, together with those of previous studies, suggest that the behaviour of influenza viruses in infant rats may be an indication for virus virulence for man, and thus provide a test which could facilitate the development of live, attenuated virus vaccines. | en_US |
dc.format.extent | 793781 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Biomedicine | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Infectious Diseases | en_US |
dc.subject.other | Virology | en_US |
dc.title | Influenza virus infection of newborn rats: Virulence of recombinant strains prepared from a cold-adapted, attenuated parent | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | School of Public Health, University of Michigan, Ann Arbor, Michigan, USA | en_US |
dc.contributor.affiliationother | Academic Division of Pathology, Department of Virology, University of Sheffield Medical School, Sheffield, England | en_US |
dc.contributor.affiliationother | Academic Division of Pathology, Department of Virology, University of Sheffield Medical School, Sheffield, England | en_US |
dc.contributor.affiliationother | Academic Division of Pathology, Department of Virology, University of Sheffield Medical School, Sheffield, England | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 496643 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41687/1/705_2005_Article_BF01318055.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01318055 | en_US |
dc.identifier.source | Archives of Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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