Cold-adapted reassortants of influenza A virus: Pathogenicity of A/Ann Arbor/6/60×A/Alaska/6/77 reassortant viruses In vivo and In vitro
dc.contributor.author | Potter, C. W. | en_US |
dc.contributor.author | Heath, A. W. | en_US |
dc.contributor.author | Maassab, Hunein F. | en_US |
dc.contributor.author | DeBorde, Dan C. | en_US |
dc.contributor.author | Odagiri, Takato | en_US |
dc.date.accessioned | 2006-09-08T19:32:03Z | |
dc.date.available | 2006-09-08T19:32:03Z | |
dc.date.issued | 1986-03 | en_US |
dc.identifier.citation | Heath, A. W.; Maassab, H. F.; Odagiri, T.; DeBorde, D. C.; Potter, C. W.; (1986). "Cold-adapted reassortants of influenza A virus: Pathogenicity of A/Ann Arbor/6/60×A/Alaska/6/77 reassortant viruses In vivo and In vitro ." Archives of Virology 91 (1-2): 53-60. <http://hdl.handle.net/2027.42/41693> | en_US |
dc.identifier.issn | 1432-8798 | en_US |
dc.identifier.issn | 0304-8608 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41693 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=3753204&dopt=citation | en_US |
dc.description.abstract | Cold-adapted reassortants of A/Ann Arbor/6/60×A/Alaska/6/77 viruses made in MDCK cells have recently been assessed genotypically and for temperature-sensitive and cold-adapted phenotypes. These reassortants were used to infect ferrets and hamsters and to inoculate organ cultures of hamster tracheal rings, in order to assess their degree of virulence. Virulence in the three model systems corresponded quite well, and a correlation between loss of virulence and particular A/AA/6/60 genes present in the reassortants was noted. Two different reassortants containing either RNA 2 or RNA 5 (NA gene) alone from A/AA/6/60 showed little attenuation from the wild-type parent. A reassortant containing both RNA2 and the NA gene from A/AA/6/60 and all remaining wild-type genes showed some small decrease in virulence compared to the wild-type virus. However a reassortant containing these two A/AA/6/60 genes and RNA 3 as an additional gene from this parent, had a level of attenuation comparable to that of the cold-adapted virus. | en_US |
dc.format.extent | 618552 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | Infectious Diseases | en_US |
dc.subject.other | Virology | en_US |
dc.subject.other | Medical Microbiology | en_US |
dc.subject.other | Biomedicine | en_US |
dc.title | Cold-adapted reassortants of influenza A virus: Pathogenicity of A/Ann Arbor/6/60×A/Alaska/6/77 reassortant viruses In vivo and In vitro | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Virology, University of Sheffield Medical School, Sheffield, U.K.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, U.S.A.; Department of Bacteriology, Tohoku University, School of Medicine, 2-1 Seiromachai, Sendai, Japan | en_US |
dc.contributor.affiliationum | Department of Virology, University of Sheffield Medical School, Sheffield, U.K.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, U.S.A.; Department of Bacteriology, Tohoku University, School of Medicine, 2-1 Seiromachai, Sendai, Japan | en_US |
dc.contributor.affiliationum | Department of Virology, University of Sheffield Medical School, Sheffield, U.K.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, U.S.A.; Department of Bacteriology, Tohoku University, School of Medicine, 2-1 Seiromachai, Sendai, Japan | en_US |
dc.contributor.affiliationum | Department of Virology, University of Sheffield Medical School, Sheffield, U.K.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, U.S.A.; Department of Bacteriology, Tohoku University, School of Medicine, 2-1 Seiromachai, Sendai, Japan | en_US |
dc.contributor.affiliationum | Department of Virology, University of Sheffield Medical School, Sheffield, U.K.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, U.S.A.; Department of Bacteriology, Tohoku University, School of Medicine, 2-1 Seiromachai, Sendai, Japan; Department of Immunology, St. Georges Hospital Medical School, Cranmer Terrace, SW 17 ORE, London, U.K. | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 3753204 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41693/1/705_2005_Article_BF01316727.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/BF01316727 | en_US |
dc.identifier.source | Archives of Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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