Acute inhibition of nitric oxide exacerbates airway hyperresponsiveness, eosinophilia and C-C chemokine generation in a murine model of fungal asthma
dc.contributor.author | Hogaboam, Cory M. | en_US |
dc.contributor.author | Blease, K. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.date.accessioned | 2006-09-08T19:40:25Z | |
dc.date.available | 2006-09-08T19:40:25Z | |
dc.date.issued | 2000-06 | en_US |
dc.identifier.citation | Blease, K.; Kunkel, S.L.; Hogaboam, C.M.; (2000). "Acute inhibition of nitric oxide exacerbates airway hyperresponsiveness, eosinophilia and C-C chemokine generation in a murine model of fungal asthma." Inflammation Research 49(6): 297-304. <http://hdl.handle.net/2027.42/41821> | en_US |
dc.identifier.issn | 1023-3830 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41821 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10939620&dopt=citation | en_US |
dc.description.abstract | Objective and Design: This study examined he role of nitric oxide in changes in airway physiology and inflammation in a murine model of fungal allergy induced by Aspergillus fumigatus (A. fumigatus) by treatment of A. fumigatus-sensitized mice with NG-nitro-L-arginine methyl ester (L-NAME) or D-NAME (8 mg/kg; i.p.).¶ Materials and Methods: Female CBA/J mice received A. fumigatus antigen dissolved in incomplete Freund's adjuvant (10 mg/100 ml i.p. and s.c.) followed 2 weeks later by A. fumigatus antigens (20 mg; i.n.) and a subsequent i.t. challenge 4 days later. Airway physiology and inflammation were examined (24 to 72 h) following i.t. challenge.¶ Results: L-NAME-treated mice had lower lung nitrite levels 24 h after A. fumigatus challenge, but higher airway hyperresponsiveness and inflammation compared to D-NAME controls. Airway inflammation in the L-NAME treatment group (72 h) was characterized by a greater bronchoalveolar lavage (BAL), peribronchial eosinophilia and augmented levels of CC chemokines compared to controls.¶ Conclusions: These findings suggest that nitric oxide is an important modulator of airway hyperresponsiveness, inflammation and C-C chemokine generation during allergic airway responses to A. fumigatus. | en_US |
dc.format.extent | 238623 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Birkhäuser Verlag; Birkhäuser Verlag, ; Springer Science+Business Media | en_US |
dc.subject.other | Key Words: Aspergillus Fumigatus — Nitric Oxide — Eosinophil — Asthma — Chemokines | en_US |
dc.subject.other | Legacy | en_US |
dc.title | Acute inhibition of nitric oxide exacerbates airway hyperresponsiveness, eosinophilia and C-C chemokine generation in a murine model of fungal asthma | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 5214 Med. Sci. I, 1301 Catherine Rd. Ann Arbor MI, 48109-0602, USA, Fax: 734-764-2397, e-mail: hogaboam@path.med.umich.edu, US, | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 5214 Med. Sci. I, 1301 Catherine Rd. Ann Arbor MI, 48109-0602, USA, Fax: 734-764-2397, e-mail: hogaboam@path.med.umich.edu, US, | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 5214 Med. Sci. I, 1301 Catherine Rd. Ann Arbor MI, 48109-0602, USA, Fax: 734-764-2397, e-mail: hogaboam@path.med.umich.edu, US, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10939620 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41821/1/11-49-6-297_00490297.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/PL00000210 | en_US |
dc.identifier.source | Inflammation Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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