IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2
dc.contributor.author | Hogaboam, Cory M. | en_US |
dc.contributor.author | Blease, K. | en_US |
dc.contributor.author | Kunkel, Steven L. | en_US |
dc.date.accessioned | 2006-09-08T19:40:33Z | |
dc.date.available | 2006-09-08T19:40:33Z | |
dc.date.issued | 2001-11 | en_US |
dc.identifier.citation | Blease, K.; Kunkel, S. L.; Hogaboam, C. M.; (2001). "IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2." Inflammation Research 50(11): 552-560. <http://hdl.handle.net/2027.42/41823> | en_US |
dc.identifier.issn | 1023-3830 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41823 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11766995&dopt=citation | en_US |
dc.description.abstract | Fungus-induced asthmatic disease is characterized by persistent airway hyperreactivity and remodeling.¶ Objective and design: To determine the role of IL-18 in the allergic airway response to Aspergillus fumigatus conidia in a murine model of A. fumigatus -induced asthma.¶ Methods: A. fumigatus -sensitized mice were depleted of IL-18 using a polyclonal anti-IL-18 antibody for 3 days after a conidia challenge.¶ Results: Airway hyperresponsiveness and eosinophil numbers were significantly elevated 3-30 days after conidia challenge compared to the normal serum-treated group. Histological evidence showed retention of A. fumigatus conidia, airway remodeling, subepithelial fibrosis, and increased collagen deposition in the lungs of IL-18-depleted mice at day 30 after the conidia challenge. Prolonged retention of conidia in IL-18 depleted A. fumigatus -sensitized mice was associated with decreased Toll-like receptor-2 (TLR-2) expression compared with the control group.¶ Conclusions: IL-18 modulates the innate immune response against A. fumigatus conidia and prevents the development of severe fungus-induced asthmatic disease. | en_US |
dc.format.extent | 650722 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Birkhäuser Verlag; Birkhäuser Verlag, ; Springer Science+Business Media | en_US |
dc.subject.other | Key Words: Infectious Immunity - Fungi - Allergy - Lung - Inflammatory Mediators | en_US |
dc.subject.other | Legacy | en_US |
dc.title | IL-18 modulates chronic fungal asthma in a murine model; putative involvement of Toll-like receptor-2 | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor MI, 48109-0602, USA, Fax: ++1 734 764 2397, e-mail: hogaboam@med.umich.edu, US, | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor MI, 48109-0602, USA, Fax: ++1 734 764 2397, e-mail: hogaboam@med.umich.edu, US, | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, 1301 Catherine Road, Ann Arbor MI, 48109-0602, USA, Fax: ++1 734 764 2397, e-mail: hogaboam@med.umich.edu, US, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11766995 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41823/1/11-50-11-552_10500552.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/PL00000233 | en_US |
dc.identifier.source | Inflammation Research | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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