The Ras family of GTPases in cancer cell invasion
dc.contributor.author | Hernández-Alcoceba, R. | en_US |
dc.contributor.author | del Peso, L. | en_US |
dc.contributor.author | Lacal, J. C. | en_US |
dc.date.accessioned | 2006-09-08T19:40:59Z | |
dc.date.available | 2006-09-08T19:40:59Z | |
dc.date.issued | 2000-01 | en_US |
dc.identifier.citation | Hernández-Alcoceba, R.; del Peso, L.; Lacal*, J. C.; (2000). "The Ras family of GTPases in cancer cell invasion." Cellular and Molecular Life Sciences 57(1): 65-76. <http://hdl.handle.net/2027.42/41830> | en_US |
dc.identifier.issn | 1420-682X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41830 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10949581&dopt=citation | en_US |
dc.description.abstract | The ability of tumoral cells to invade surrounding tissues is a prerequisite for metastasis. This is the most life-threatening event of tumor progression, and so research is intensely focused on elucidating the mechanisms responsible for invasion and metastasis. The Ras superfamily of GTPases comprises several subfamilies of small GTP-binding proteins whose functions include the control of proliferation, differentiation, and apoptosis, as well as cytoskeleton organization. The development of metastasis is a multistep process that requires coordinated activation of proliferation, motility, changes in normal cell-to-cell and cell-to-substrate contacts, degradation of extracellular matrix, inhibition of apoptosis, and adaptation to an inappropriate tissue environment. Several members of the Ras superfamily of proteins have been implicated in these processes. The present review summarizes the current knowledge in this field. | en_US |
dc.format.extent | 141663 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Birkhäuser Verlag; Birkhäuser Verlag Basel, ; Springer Science+Business Media | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Key Words. Ras; Rho; Metastasis; Invasion; Cytoskeleton; Adhesion; Apoptosis. | en_US |
dc.title | The Ras family of GTPases in cancer cell invasion | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor (Michigan 48109, USA), AL, | en_US |
dc.contributor.affiliationum | Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor (Michigan 48109, USA), AL, | en_US |
dc.contributor.affiliationother | Instituto de Investigaciones Biomédicas, c/Arturo Duperier, 4., E-28029 Madrid (Spain), Fax +3491 585 4606, e-mail: jclacal@iib.uam.es, ES, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10949581 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41830/1/18-57-1-65_00570065.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s000180050499 | en_US |
dc.identifier.source | Cellular and Molecular Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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