Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle
dc.contributor.author | Cooper, Saul | en_US |
dc.contributor.author | Shayman, J. A. | en_US |
dc.date.accessioned | 2006-09-08T19:41:11Z | |
dc.date.available | 2006-09-08T19:41:11Z | |
dc.date.issued | 2001-04 | en_US |
dc.identifier.citation | Cooper, S.; Shayman, J.A.; (2001). "Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle." Cellular and Molecular Life Sciences 58(4): 580-595. <http://hdl.handle.net/2027.42/41833> | en_US |
dc.identifier.issn | 1420-682X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41833 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11361093&dopt=citation | en_US |
dc.description.abstract | It is widely accepted that phosphorylation of the retinoblastoma (Rb) protein during the G1 phase of the mammalian division cycle is a major control element regulating passage of cells into S phase and through the division cycle. The experiments supporting G1-phase-specific Rb phosphorylation and the historical development of this idea are reviewed. By making a rigorous distinction between 'growth cessation' and the phenomena of 'cell cycle exit' or 'G1-phase arrest', the evidence for the G1-phase-specific phosphorylation of Rb protein is reinterpreted. We show that the evidence for G1-phase phosphorylation of Rb rests on few experiments and a chain of reasoning with some weak links. Evidence is reviewed that growth conditions regulate the phosphorylation of Rb. A growth-regulated control system that is independent of the cell cycle explains much of the evidence adduced to support cycle-specific phosphorylation of Rb. We propose that additional experimental evidence is needed to decide whether there is a G1-phase-specific phosphorylation of Rb protein. | en_US |
dc.format.extent | 139905 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Birkhäuser Verlag; Birkhäuser Verlag, ; Springer Science+Business Media | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Key Words. G1 Phase; Cell Cycle; G1-phase Arrest; Phosphorylation. | en_US |
dc.title | Revisiting retinoblastoma protein phosphorylation during the mammalian cell cycle | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Science (General) | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor (Michigan 48109-0620, USA), Fax +1 734 764 3562, e-mail: cooper@umich.edu, US, | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor (Michigan 48109-0620, USA), Fax +1 734 764 3562, e-mail: cooper@umich.edu, US, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11361093 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41833/1/18-58-4-580_10580580.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/PL00000883 | en_US |
dc.identifier.source | Cellular and Molecular Life Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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