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Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats
dc.contributor.authorFrank, R. N.en_US
dc.contributor.authorKennedy, A.en_US
dc.contributor.authorStockert, C. M.en_US
dc.contributor.authorFathallah, L.en_US
dc.contributor.authorObrosova, I. G.en_US
dc.contributor.authorMinchenko, A. G.en_US
dc.contributor.authorMarinescu, V.en_US
dc.contributor.authorStevens, Martin J.en_US
dc.date.accessioned2006-09-08T19:44:52Z
dc.date.available2006-09-08T19:44:52Z
dc.date.issued2001-09en_US
dc.identifier.citationObrosova, I. G.; Minchenko, A. G.; Marinescu, V.; Fathallah, L.; Kennedy, A.; Stockert, C. M.; Frank, R. N.; Stevens, M. J.; (2001). "Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats." Diabetologia 44(9): 1102-1110. <http://hdl.handle.net/2027.42/41890>en_US
dc.identifier.issn0012-186Xen_US
dc.identifier.urihttps://hdl.handle.net/2027.42/41890
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=11596663&dopt=citationen_US
dc.description.abstractA strong positive correlation has been found between lipid peroxidation product and vascular endothelial growth factor concentrations in the vitreous of patients with proliferative diabetic retinopathy. To establish a causal relation between diabetes-associated enhanced oxidative stress and vascular endothelial growth factor production, we evaluated two antioxidants, dl -α-lipoic acid and taurine, on retinal vascular endothelial growth factor protein and mRNA expression and on parameters of oxidative stress in streptozotocin-diabetic rats.en_US
dc.format.extent172322 bytes
dc.format.extent3115 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.language.isoen_US
dc.publisherSpringer-Verlag; Springer-Verlag Berlin Heidelbergen_US
dc.subject.otherKeywords Ascorbate, Lipid Peroxidation, Dl-α-Lipoic Acid, Oxidative Stress, Rat, Retina, Sorbitol Pathway of Glucose Metabolism, Streptozotocin-diabetes, Taurine, Vascular Endothelial Growth Factor.en_US
dc.subject.otherLegacyen_US
dc.titleAntioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic ratsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Centre, Ann Arbor, Michigan, USA, US,en_US
dc.contributor.affiliationumDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Centre, Ann Arbor, Michigan, USA, US,en_US
dc.contributor.affiliationumDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Centre, Ann Arbor, Michigan, USA, US,en_US
dc.contributor.affiliationumDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Centre, Ann Arbor, Michigan, USA, US,en_US
dc.contributor.affiliationumDivision of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Centre, Ann Arbor, Michigan, USA, US,en_US
dc.contributor.affiliationotherDepartment of Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan, USA, US,en_US
dc.contributor.affiliationotherDepartment of Anesthesiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA, US,en_US
dc.contributor.affiliationotherDepartment of Ophthalmology, Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan, USA, US,en_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid11596663en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/41890/1/125-44-9-1102_10441102.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1007/s001250100631en_US
dc.identifier.sourceDiabetologiaen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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