Naltrexone reduces ethanol- and sucrose-reinforced responding in rhesus monkeys
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Pakarinen, Eric D. | en_US |
dc.contributor.author | Williams, Keith L. | en_US |
dc.contributor.author | Winger, Gail D. | en_US |
dc.date.accessioned | 2006-09-08T19:49:22Z | |
dc.date.available | 2006-09-08T19:49:22Z | |
dc.date.issued | 1998-09 | en_US |
dc.identifier.citation | Williams, K. L.; Winger, Gail; Pakarinen, Eric D.; Woods, James H.; (1998). "Naltrexone reduces ethanol- and sucrose-reinforced responding in rhesus monkeys." Psychopharmacology 139 (1-2): 53-61. <http://hdl.handle.net/2027.42/41961> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41961 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9768542&dopt=citation | en_US |
dc.description.abstract | These experiments evaluated the ability of naltrexone (NTX) to reduce selectively oral and IV ethanol-reinforced responding, and examined the ethanol-NTX interaction in terms of the competitive opioid antagonist property of NTX. Five rhesus monkeys self-administered ethanol or sucrose and concurrently available water. Ethanol concentration was varied from 0.25% to 8% (w/v). Naltrexone (0.032–0.32 mg/kg) or saline was given IM 30 min prior to some drinking sessions. NTX (0.32 mg/kg) reduced ethanol-reinforced responding at the concentration that maintained the most responding (1% or 2%). NTX (0.1 mg/kg) reduced ethanol-reinforced responding, both at a low ethanol concentration (0.25%) that produced little ethanol intake (g/kg), and at a higher concentration (4%) with an appreciable intake. Thus, NTX (0.1 mg/kg) shifted the ethanol concentration-consumption curve down, in an insurmountable manner. NTX (0.1 and 0.32 mg/kg) also reduced reinforced responding for sucrose 100 g/l. In another experiment, three rhesus monkeys were given opportunities to self-administer ethanol IV. NTX (0.1 mg/kg) reduced the number of ethanol injections obtained by the monkeys at all ethanol doses tested (0.01, 0.032, and 0.1 g/kg per injection).The dose-effect curve was also shifted down. These results showed that NTX reduced behavior maintained by either ethanol or sucrose non-selectively. Furthermore, the ability of NTX to suppress ethanol-reinforced responding did not depend on the route of ethanol administration and was not overcome by increasing the concentration or dose per injection of ethanol. | en_US |
dc.format.extent | 171866 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Operant Behavior | en_US |
dc.subject.other | Alcohol | en_US |
dc.subject.other | Oral Self-administration | en_US |
dc.subject.other | Key Words Opioid Antagonists | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Intravenous Self-administration | en_US |
dc.title | Naltrexone reduces ethanol- and sucrose-reinforced responding in rhesus monkeys | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | 1301 MSRB III, Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632, USA, US | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632, USA, US | en_US |
dc.contributor.affiliationum | 1301 MSRB III, Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632, USA, US | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-0632, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 9768542 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41961/1/213-139-1-2-53_81390053.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s002130050689 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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