Local administration of Δ9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action
dc.contributor.author | Ko, Mei-Chuan | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.date.accessioned | 2006-09-08T19:49:33Z | |
dc.date.available | 2006-09-08T19:49:33Z | |
dc.date.issued | 1999-04 | en_US |
dc.identifier.citation | Ko, M.-C.; Woods, James H.; (1999). "Local administration of Δ9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action." Psychopharmacology 143(3): 322-326. <http://hdl.handle.net/2027.42/41964> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41964 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10353438&dopt=citation | en_US |
dc.description.abstract | Rationale: Cannabinoids can reduce nociceptive responses by acting on peripheral cannabinoid receptors in rodents. Objectives: The study was conducted to evaluate the hypothesis that local administration of Δ 9 -tetrahydrocannabinol (Δ 9 -THC) can attenuate capsaicin-induced nociception in rhesus monkeys. Methods: Capsaicin (100 µg) was applied locally in the tail of rhesus monkeys to evoke a nociceptive response, thermal allodynia, in normally innocuous 46°C water. Δ 9 -THC (10–320 µg) was coadministered with capsaicin in the tail to assess local antinociceptive effects. In addition, a local antagonism study was performed to confirm the selectivity of Δ 9 -THC action. Results: Δ 9 -THC dose-dependently inhibited capsaicin-induced allodynia. This local antinociception was antagonized by small doses (10–100 µg) of the cannabinoid CB 1 antagonist, SR141716A, applied in the tail. However, 100 µg SR141716A injected subcutaneously in the back did not antagonize local Δ 9 -THC. Conclusions: These results indicate that the site of action of locally applied Δ 9 -THC is in the tail. It provides functional evidence that activation of peripheral cannabinoid CB 1 receptors can attenuate capsaicin-induced thermal nociception in non-human primates and suggests a new approach for cannabinoids in pain management. | en_US |
dc.format.extent | 67911 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Antinociception | en_US |
dc.subject.other | Key Words Capsaicin | en_US |
dc.subject.other | Peripheral Cannabinoid Receptor | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Inflammatory Pain | en_US |
dc.title | Local administration of Δ9-tetrahydrocannabinol attenuates capsaicin-induced thermal nociception in rhesus monkeys: a peripheral cannabinoid action | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Medical School, 1301 MSRB III, Ann Arbor, MI 48109-0632, USA, e-mail: mko@umich.edu, Fax: +1-734-764-7118, US, | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Medical School, 1301 MSRB III, Ann Arbor, MI 48109-0632, USA, e-mail: mko@umich.edu, Fax: +1-734-764-7118, US, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10353438 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41964/1/213-143-3-322_91430322.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s002130050955 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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