3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serontonergic involvement
dc.contributor.author | Winger, Gail D. | en_US |
dc.contributor.author | Rice, Kenner C. | en_US |
dc.contributor.author | Woods, James H. | en_US |
dc.contributor.author | Ullrich, Thomas | en_US |
dc.contributor.author | Fantegrossi, William E. | en_US |
dc.date.accessioned | 2006-09-08T19:50:31Z | |
dc.date.available | 2006-09-08T19:50:31Z | |
dc.date.issued | 2002-06 | en_US |
dc.identifier.citation | Fantegrossi, William E.; Ullrich, Thomas; Rice, Kenner C.; Woods, James H.; Winger, Gail; (2002). "3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serontonergic involvement." Psychopharmacology 161(4): 356-364. <http://hdl.handle.net/2027.42/41979> | en_US |
dc.identifier.issn | 0033-3158 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/41979 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=12073162&dopt=citation | en_US |
dc.description.abstract | Rationale: The reinforcing effects of MDMA and its enantiomers have not been extensively characterized in laboratory animals. Objectives: To investigate whether MDMA and its stereoisomers would be self-administered intravenously by rhesus monkeys ( Macaca mulatta ), and to assess the effects of serotonin 2 receptor antagonists on MDMA-maintained responding. Methods: Four adult male rhesus monkeys were maintained on a fixed ratio 10, time-out 60-s schedule for 0.01 mg/kg cocaine or saline injections. Racemic MDMA and its stereoisomers, and racemic methamphetamine were periodically substituted for cocaine or saline. In subsequent antagonist experiments, five adult rhesus monkeys (three male, two female) were maintained on a multiple dose fixed ratio 30, time-out 45-s schedule for cocaine or saline injections. Racemic MDMA and its enantiomers were periodically substituted for cocaine or saline, with or without a pre-session injection of the serotonin 2 receptor antagonists ketanserin or MDL100907. Results: In the initial self-administration experiments, MDMA and its stereoisomers generated "inverted U"-shaped self-administration curves across the dose range tested. Racemic MDMA doses between 0.01 and 0.1 mg/kg per injection, S(+)-MDMA doses between 0.003 and 0.1 mg/kg per injection, and R(–)-MDMA doses between 0.01 and 0.1 mg/kg per injection engendered more responding than saline; however, no dose of any form of MDMA maintained as much behavior as cocaine or methamphetamine. In subsequent antagonist experiments, pretreatments with 0.1 or 0.3 mg/kg ketanserin or MDL100907 attenuated responding for S(+)-MDMA, and completely abolished responding for R(–)-MDMA, but did not affect cocaine-maintained behavior. Conclusions: MDMA and its stereoisomers serve as reinforcers in rhesus monkeys. We suggest that stimulation of 5-HT 2A receptors is integral to the reinforcing effects of MDMA. | en_US |
dc.format.extent | 164044 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag | en_US |
dc.subject.other | MDMA Self-administration Serotonin Antagonist Rhesus Monkey Amphetamine | en_US |
dc.subject.other | Legacy | en_US |
dc.title | 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serontonergic involvement | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbsecondlevel | Neurosciences | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychology (Biopsychology Program), University of Michigan, Ann Arbor, MI 48109-1109, USA, | en_US |
dc.contributor.affiliationum | Department of Psychology (Biopsychology Program), University of Michigan, Ann Arbor, MI 48109-1109, USA, | en_US |
dc.contributor.affiliationum | Department of Pharmacology, University of Michigan, Medical School, 1301 MSRB III, Ann Arbor, MI 48109-0632, USA, | en_US |
dc.contributor.affiliationother | Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Building 8, Room B1-21, Bethesda, MD 20892, USA, | en_US |
dc.contributor.affiliationother | Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Building 8, Room B1-21, Bethesda, MD 20892, USA, | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 12073162 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/41979/1/213-161-4-356_s00213-002-1021-6.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s00213-002-1021-6 | en_US |
dc.identifier.source | Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.