Capabilities of two- and three-dimensional FDG-PET for detecting small lesions and lymph nodes in the upper torso: a dynamic phantom study
dc.contributor.author | Raylman, Raymond R. | en_US |
dc.contributor.author | Wahl, Richard L. | en_US |
dc.contributor.author | Kison, Paul V. | en_US |
dc.date.accessioned | 2006-09-08T19:56:37Z | |
dc.date.available | 2006-09-08T19:56:37Z | |
dc.date.issued | 1999-01 | en_US |
dc.identifier.citation | Raylman, Raymond R.; Kison, Paul V.; Wahl, Richard L.; (1999). "Capabilities of two- and three-dimensional FDG-PET for detecting small lesions and lymph nodes in the upper torso: a dynamic phantom study." European Journal of Nuclear Medicine 26(1): 39-45. <http://hdl.handle.net/2027.42/42075> | en_US |
dc.identifier.issn | 0340-6997 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42075 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9933660&dopt=citation | en_US |
dc.description.abstract | The capabilities and limitations of two-(2D) and three-dimensional (3D) fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting small tumors and lymph nodes were studied in a phantom modeling the human chest and axilla. Multiple dual-radionuclide phantom studies were performed. Five hollow spheres ranging in diameter from 3 mm to 15 mm were filled with carbon-11 and placed in the axillary and mediastinal regions of an anthropomorphic phantom containing hollow organs filled with 18 F to simulate FDG uptake 1 h after injection. Dynamic imaging was performed to acquire PET images with varying target-to-background ratios. Imaging was performed in 2D and 3D acquisition modes, with and without attenuation correction, on a modern PET scanner. Lesion detectability was visually and quantitatively assessed. For objects larger than 9 mm in diameter, target-to-background ratios ranging from ∼3:1 to ∼10:1 were detectable. Objects < 9 mm in diameter required a target-to-background ratio of ≥18:1. Target-to-background ratios required for lesion detectability were equivalent for 2D and 3D PET images with and without attenuation correction. In conclusion, 2D and 3D PET with attenuation correction consistently detected ”tumors”≥ 9 mm. Lesions < 9 mm could be detected if there was high enough tumor uptake. No statistically significant differences in lesion detection were found for 2D versus 3D PET, or for attenuation-corrected versus non-attenuation-corrected images. | en_US |
dc.format.extent | 92621 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Key Words: Positron Emission Tomography | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Tumor Detection | en_US |
dc.subject.other | Nuclear Medicine | en_US |
dc.title | Capabilities of two- and three-dimensional FDG-PET for detecting small lesions and lymph nodes in the upper torso: a dynamic phantom study | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan School of Medicine, USA, US | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, University of Michigan School of Medicine, USA, US | en_US |
dc.contributor.affiliationother | Department of Radiology, West Virginia University School of Medicine, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 9933660 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42075/1/259-26-1-39_90260039.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s002590050357 | en_US |
dc.identifier.source | European Journal of Nuclear Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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