Uptake of positron emission tomography tracers in experimental bacterial infections: a comparative biodistribution study of radiolabeled FDG, thymidine, l -methionine, 67 Ga-citrate, and 125 I-HSA
dc.contributor.author | Fisher, Susan J. | en_US |
dc.contributor.author | Wahl, Richard L. | en_US |
dc.contributor.author | Sugawara, Yoshifumi | en_US |
dc.contributor.author | Brown, Raya S. | en_US |
dc.contributor.author | Gutowski, Tomasz D. | en_US |
dc.date.accessioned | 2006-09-08T19:56:41Z | |
dc.date.available | 2006-09-08T19:56:41Z | |
dc.date.issued | 1999-04 | en_US |
dc.identifier.citation | Sugawara, Yoshifumi; Gutowski, Tomasz D.; Fisher, Susan J.; Brown, Raya S.; Wahl, Richard L.; (1999). "Uptake of positron emission tomography tracers in experimental bacterial infections: a comparative biodistribution study of radiolabeled FDG, thymidine, l -methionine, 67 Ga-citrate, and 125 I-HSA." European Journal of Nuclear Medicine 26(4): 333-341. <http://hdl.handle.net/2027.42/42076> | en_US |
dc.identifier.issn | 0340-6997 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42076 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=10199938&dopt=citation | en_US |
dc.description.abstract | The purpose of this study was to evaluate the localization of positron emission tomography (PET) tracers [2-deoxy-2-fluoro- d -glucose (FDG), thymidine, and l -methionine] in sites of bacterial infection, and to contrast this with that of other tracers. The left calf muscles of rats were infected with a suspension of Escherichia coli and the biodistribution of 18 F- or 3 H-FDG, 3 H-thymidine, l - 11 C- or 3 H-methionine, gallium-67 citrate ( 67 Ga-citrate) and iodine-125 human serum albumin ( 125 I-HSA) was determined in these animals. 3 H-FDG uptake in the infectious foci was evaluated by autoradiography of histological sections. Although 18 F-FDG, 67 Ga-citrate, and 125 I-HSA showed comparatively high uptake in the infected muscle [the percentage activity of injected dose (ID) per gram of tissue normalized for rat weight in kilogram (%ID/g)×kg at 2 h postinjection was as follows: 18 F-FDG, 0.184±0.026 to 0.218±0.046; 67 Ga-citrate, 0.221±0.016; 125 I-HSA, 0.198±0.019], the infected muscle to blood ratio was much higher for 18 F-FDG than for 67 Ga-citrate or 125 I-HSA ( 18 F-FDG, 10.31±0.76 to 14.89±2.26; 67 Ga-citrate, 1.24±0.67; 125 I-HSA, 0.20±0.02). The draining reactive lymph nodes also showed higher accumulation of 18 F-FDG than of 67 Ga-citrate or 125 I-HSA. The uptake of 3 H-thymidine and l - 11 C- or 3 H-methionine in the infected muscle was lower than that of 18 F- or 3 H-FDG (at 2 h postinjection, 3 H-thymidine = 0.039±0.005 and L- 3 H-methionine = 0.063±0.007 (%ID/g)×kg. Autoradiographs showed that the highest 3 H-FDG uptake was seen in the area of inflammatory cell infiltration surrounding the necrotic region. In conclusion, 18 F-FDG, which rapidly accumulates in sites of bacterial infection and in reactive lymph nodes with a high target to background ratio, appears to be a promising infection detection agent. | en_US |
dc.format.extent | 220678 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Thymidine | en_US |
dc.subject.other | Fluorodeoxyglucose | en_US |
dc.subject.other | Gallium-67 Citrate | en_US |
dc.subject.other | L-Methionine | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Key Words: Bacterial Infection | en_US |
dc.title | Uptake of positron emission tomography tracers in experimental bacterial infections: a comparative biodistribution study of radiolabeled FDG, thymidine, l -methionine, 67 Ga-citrate, and 125 I-HSA | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Radiology | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationum | Division of Nuclear Medicine, Department of Internal Medicine, The University of Michigan Medical Center, Ann Arbor, Michigan, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 10199938 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42076/1/259-26-4-333_90260333.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s002590050395 | en_US |
dc.identifier.source | European Journal of Nuclear Medicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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