Coordinate control and variation in X-linked gene expression among female mice
dc.contributor.author | Burke, David T. | en_US |
dc.contributor.author | Greenwood, Alex D. | en_US |
dc.contributor.author | Southard-Smith, E. Michelle | en_US |
dc.contributor.author | Galecki, Andrzej T. | en_US |
dc.date.accessioned | 2006-09-08T20:00:36Z | |
dc.date.available | 2006-09-08T20:00:36Z | |
dc.date.issued | 1997-11 | en_US |
dc.identifier.citation | Greenwood, Alex D.; Southard-Smith, E. Michelle; Galecki, Andrzej T.; Burke, David T.; (1997). "Coordinate control and variation in X-linked gene expression among female mice." Mammalian Genome 8(11): 818-822. <http://hdl.handle.net/2027.42/42137> | en_US |
dc.identifier.issn | 0938-8990 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42137 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9337393&dopt=citation | en_US |
dc.description.abstract | In normal female mammals, one of the two X Chromosome (Chr) homologs per cell is silenced coordinately during early embryogenesis. The genes located on the inactivated X homolog are predicted to be influenced by the same underlying repression mechanism. To test the uniformity of cis -acting gene repression, 32 genetically identical F 1 female mice were analyzed for differential expression of homologous alleles at three X-linked genes— Otc, Atp7a (=Mottled), and Hprt. Gene expression was assayed by the single-nucleotide primer extension (SNuPE) method, thereby allowing the three genes to be quantitated from the same RNA sample. Although variable between individual animals, the relative expression of the two alleles ( allelic expression ratio ) of the genes is significantly correlated within each steady-state RNA pool. When examined by animal age (3 months to 12 months), no statistically significant differences were observed in the mean or variance of allelic expression ratio. Together, the results confirm that X inactivation is coordinately controlled and is stable across the early- to mid-adult life span. | en_US |
dc.format.extent | 501771 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag New York Inc. | en_US |
dc.subject.other | Legacy | en_US |
dc.title | Coordinate control and variation in X-linked gene expression among female mice | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, 1150 West Medical Center Drive, University of Michigan, Ann Arbor, Michigan 48109-0618, USA, US | en_US |
dc.contributor.affiliationum | Department of Human Genetics, 1150 West Medical Center Drive, University of Michigan, Ann Arbor, Michigan 48109-0618, USA, US | en_US |
dc.contributor.affiliationum | Institute of Gerontology, University of Michigan, Ann Arbor, MI 48109, USA, US | en_US |
dc.contributor.affiliationum | Department of Human Genetics, 1150 West Medical Center Drive, University of Michigan, Ann Arbor, Michigan 48109-0618, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 9337393 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42137/1/335-8-11-818_8n11p818.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s003359900585 | en_US |
dc.identifier.source | Mammalian Genome | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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