Naturally occurring genetic variation affects Drosophila photoreceptor determination
dc.contributor.author | Gibson, Greg | en_US |
dc.contributor.author | Gasperini, Robert | en_US |
dc.contributor.author | Polaczyk, P. J. | en_US |
dc.date.accessioned | 2006-09-08T20:07:36Z | |
dc.date.available | 2006-09-08T20:07:36Z | |
dc.date.issued | 1998-02 | en_US |
dc.identifier.citation | Polaczyk, P. J.; Gasperini, Robert; Gibson, G.; (1998). "Naturally occurring genetic variation affects Drosophila photoreceptor determination." Development, Genes and Evolution 207(7): 462-470. <http://hdl.handle.net/2027.42/42245> | en_US |
dc.identifier.issn | 0949-944X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/42245 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9510541&dopt=citation | en_US |
dc.description.abstract | The signal transduction pathway controlling determination of the identity of the R7 photoreceptor in the Drosophila eye is shown to harbor high levels of naturally occurring genetic variation. The number of ectopic R7 cells induced by the dosage-sensitive Sev S11.1 transgene that encodes a mildly activated form of the Sevenless tyrosine kinase receptor is highly sensitive to the wild-type genetic background. Phenotypes range from complete suppression to massive overproduction of photoreceptors that exceeds reported effects of known single gene modifiers, and are to some extent sex-dependent. Signaling from the dominant gain-of-function Drosophila Epidermal Growth Factor Receptor ( DER-Ellipse ) mutations is also sensitive to the genetic backgrounds, but there is no correlation with the effects on Sev S11.1 . This implies that different genes and/or alleles modify the two activated receptor genotypes. The evolutionary significance of the existence of high levels of genetic variation in the absence of normal phenotypic variation is discussed. | en_US |
dc.format.extent | 718564 bytes | |
dc.format.extent | 3115 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.language.iso | en_US | |
dc.publisher | Springer-Verlag; Springer-Verlag Berlin Heidelberg | en_US |
dc.subject.other | Photoreceptor | en_US |
dc.subject.other | EGF Receptor | en_US |
dc.subject.other | Key Words Genetic Variation | en_US |
dc.subject.other | Legacy | en_US |
dc.subject.other | Sevenless | en_US |
dc.subject.other | Drosophila | en_US |
dc.title | Naturally occurring genetic variation affects Drosophila photoreceptor determination | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109-1048, USA, US | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109-1048, USA, US | en_US |
dc.contributor.affiliationum | Department of Biology, University of Michigan, Natural Science Building, Ann Arbor, MI 48109-1048, USA, US | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 9510541 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/42245/1/427-207-7-462_82070462.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1007/s004270050137 | en_US |
dc.identifier.source | Development, Genes and Evolution | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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